Gut microbiota and transcriptome analysis reveals a genetic component to dropping moisture in chickens

文献类型： 外文期刊

第一作者： Zhang, Tongyu

作者： Zhang, Tongyu;Zhu, Tao;Wen, Junhui;Qu, Lujiang;Ning, Zhonghua;Chen, Yu;Wang, Liang;Lv, Xueze;Yang, Weifang;Jia, Yaxiong;Qu, Changqing;Li, Haiying;Wang, Huie

作者机构：

关键词： dropping moisture; heritability; chicken; transcriptome; gut microbiota

期刊名称：POULTRY SCIENCE （ 影响因子：4.4； 五年影响因子：4.4 ）

ISSN： 0032-5791

年卷期： 2023 年 102 卷 5 期

页码：

收录情况： SCI

摘要： High dropping moisture (DM) in poultry production has deleterious effects on the environment, feeding cost, and public health of people and animals. To explore the contributing genetic components, we classified DM of 67-wk-old Rhode Island Red (RIR) hens at 4 differ-ent levels and evaluated the underlying genetic heritabil-ity. We found the heritability of DM to be 0.219, indicating a moderately heritable trait. We then selected chickens with the highest and lowest DM levels. Using transcriptome, we only detected 12 differentially expressed genes (DEGs) between these 2 groups from the spleen, and 1,507 DEGs from intestinal tissues (jejunum and cecum). The low number of DEGs observed in the spleen suggests that differing moisture levels are not attributed to pathogenic infection. Fourteen of the intestinal high expressed genes are associated with water-salt metabolism (WSM). We also investigated the gut microbial composi-tion by 16S rRNA gene amplicon sequencing. Six different microbial operational taxonomic units (OTUs) (Cetobac-terium, Sterolibacterium, Elusimicrobium, Roseburia, Faecalicoccus, and Megamonas) between the 2 groups from jejunum and cecum are potentially biomarkers related to DM levels. Our results identify a genetic compo-nent to chicken DM, and can guide breeding strategies.

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