A modified withdrawal time estimation and risk assessment of enrofloxacin in grass carp (Ctenopharyngodon idella) after ad libitum medicated feed based on statistical approaches in natural cultured environments

文献类型： 外文期刊

第一作者： Xu, Ning

作者： Xu, Ning;Zhang, Huan;Dong, Jing;Yang, Yibin;Liu, Yongtao;Zhou, Shun;Zhu, Xia;Ai, Xiaohui;Xu, Ning;Dong, Jing;Yang, Yibin;Liu, Yongtao;Zhou, Shun;Zhu, Xia;Ai, Xiaohui;Zhang, Huan;Xu, Ning;Ai, Xiaohui

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关键词： Withdrawal time; Enrofloxacin; Risk assessment; Natural culture environments; Grass carp

期刊名称：VETERINARY RESEARCH COMMUNICATIONS （ 影响因子：1.8； 五年影响因子：1.9 ）

ISSN： 0165-7380

年卷期： 2024 年

页码：

收录情况： SCI

摘要： Enrofloxacin (EF) is a broad-spectrum and highly efficient antibiotic commonly used for treating diseases in aquatic animals. However, its abuse in aquaculture applications often leads to excess residue in tissues of grass carp (Ctenopharyngodon idella). Hence, this study aimed to estimate the withdrawal time (WT) of EF and its metabolite of ciprofloxacin (CF) administered medicated feed in natural culture environments and conduct a risk assessment. Plasma and tissue samples were gathered at appropriate time points and detected by high-performance liquid chromatography. The data homogeneity was evaluated by Bartlett's test and Cochran's test. The linearity of the regressed line was evaluated by visual inspection and F test. Outliers were estimated on a normal probability scale by plotting the standardized residual versus their cumulative frequency distribution. Finally, the WT was calculated to be 51 days in muscle + skin based on the maximum residue limit of 100 mu g/kg. After 51 days, the concentration of EF and CF fell below 10 mu g/kg. The estimated daily intake was calculated to be 0.009 mu g/kg/d. Hazard quotient was computed to be 0.002, which was far below one. These results suggested that calculated WT of EF could ensure the safety of products from grass carp for humans.

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