Insights into the mechanism of multi-walled carbon nanotubes phytotoxicity in Arabidopsis through transcriptome and m6A methylome analysis

文献类型： 外文期刊

第一作者： Yang, Zemao

作者： Yang, Zemao;Deng, Canhui;Wu, Yupeng;Dai, Zhigang;Tang, Qing;Cheng, Chaohua;Xu, Ying;Hu, Rong;Chen, Xiaojun;Zhang, Xiaoyu;Li, Alei;Su, Jianguang;Yan, An;Liu, Chan;Xiong, Xinghua;Wu, Yupeng;Yan, An;Liu, Chan;Xiong, Xinghua

作者机构：

关键词： Carbon nanotube; MWCNTs; Arabidopsis; m6A; Transcriptome; Phytotoxicity

期刊名称：SCIENCE OF THE TOTAL ENVIRONMENT （ 影响因子：7.963； 五年影响因子：7.842 ）

ISSN： 0048-9697

年卷期： 2021 年 787 卷

页码：

收录情况： SCI

摘要： With the increasing production and wide application of carbon nanotubes (CNTs), they are inevitably released into the natural environment and ecosystems, where plants are the main primary producers. Hence, it is imperative to understand the toxic effects of CNTs on plants. The molecular mechanisms underlying the toxic effects of CNTs on plants are still unclear. Therefore, in the present study, we investigated the effects of high concentrations of multi-walled CNTs (MWCNTs) on Arabidopsis. Root elongation and leaf development were severely inhibited after MWCNT exposure. Excess production of H2O2, O-2(-), and malondialdehyde was observed, indicating that MWCNTs induced oxidative stress. The antioxidant system was activated to counter MWCNTs-induced oxidative stress. Combinatorial transcriptome and m6A methylome analysis revealed that MWCNTs suppressed auxin signaling and photosynthesis. Reactive oxygen species metabolism, toxin metabolism, and plant responses to pathogens were enhanced to cope with the phytotoxicity of MWCNTs. Our results provide new insights into the molecular mechanisms of CNT phytotoxicity and plant defense responses to CNTs. (C) 2021 Elsevier B.V. All rights reserved.

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