PEDV promotes the differentiation of CD4+T cells towards Th1, Tfh, and Treg cells via CD103+DCs

文献类型： 外文期刊

第一作者： Yu, Haoyuan

作者： Yu, Haoyuan;Chen, Guohui;Zhang, Tao;Huang, Xin;Lu, Yabin;Li, Maolin;Li, Shuxian;Wang, Caiying;Li, Baoyu;Zhang, Yunhang;Liu, Guangliang;Fu, Yuguang;Fu, Yuguang

作者机构：

关键词： PEDV; CD103+DCs; CD4+T differentiation

期刊名称：VIROLOGY （ 影响因子：3.7； 五年影响因子：3.2 ）

ISSN： 0042-6822

年卷期： 2023 年 587 卷

页码：

收录情况： SCI

摘要： Porcine epidemic diarrhea virus (PEDV) can infect all ages of pigs, particularly newborn piglets with a mortality almost reaching to 80-100%, causing significant economic losses to the global pig industry. The mucosal immune response is crucial for PEDV prevention, in which specific dendritic cells (DCs) and differentiated T cells play vital roles. In this study, CD103+DCs were differentiated successfully with retinoic acid (RA) treatment in vitro. PEDV could not replicate efficiently in differentiated CD103+DCs but could promote maturation of CD103+DCs by up-regulating the expression of SLA-DR, CD1a, CD86, and cytokines of IL-1 beta and IL-10. In addition, PEDVinfected CD103+DCs and CD4+T cells were co-cultured, and the results showed that the differentiation of CD4+T cells toward Th1, Tfh, and Treg, but not Th2. These results demonstrate that PEDV-infected CD103+DCs could promote the differentiation of CD4+T cells, which provided the basis for further study of mucosal response induced by PEDV via CD103+DCs.

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