Hepatoprotective and antioxidant effects of Glycyrrhiza glabra extract against carbon tetrachloride (CCl4)-induced hepatocyte damage in common carp (Cyprinus carpio)

文献类型： 外文期刊

第一作者： Yin, Guojun

作者： Yin, Guojun;Lu, Chengping;Yin, Guojun;Cao, Liping;Xu, Pao;Jeney, Galina;Nakao, Miki

作者机构：

关键词： Glycyrrhiza glabra;Carbon tetrachloride;Hepatocytes;Hepatoprotection;Antioxidant;Cyprinus carpio

期刊名称：FISH PHYSIOLOGY AND BIOCHEMISTRY （ 影响因子：2.794； 五年影响因子：2.876 ）

ISSN： 0920-1742

年卷期： 2011 年 37 卷 1 期

页码：

收录情况： SCI

摘要： The present study is aiming at evaluating the hepatoprotective and antioxidant effects of Glycyrrhiza glabra extract (2.5, 5 and 10 mu g/ml) on the carbon tetrachloride (CCl4)-induced carp hepatocyte damage in vitro. Glycyrrhiza glabra extract was added to the carp primary hepatocytes before (pre-treatment), after (post-treatment) and both before and after (pre- and post-treatment) the incubation of the hepatocytes with CCl4. CCl4 at 8 mM in the culture medium produced significantly elevated levels of lactate dehydrogenase (LDH), glutamate oxalate transaminase (GOT), glutamate pyruvate transaminase (GPT) and malondialdehyde (MDA) and significantly reduced levels of superoxide dismutase (SOD) and glutathione peroxidase (GSH-Px). Pre-treatment (5 mu g/ml) and pre- and post-treatment (5 and 10 mu g/ml) of the hepatocytes with Glycyrrhiza glabra extract significantly reduced the elevated levels of LDH, GOT, GPT and MDA and increased the reduced levels of SOD and GSH-Px by CCl4; post-treatment of the hepatocytes with Glycyrrhiza glabra extract at 5 mu g/ml reduced the GPT and GOT levels and increased the GSH-Px level, but had no effect on the other parameters at all the studied concentrations. The results support the use of Glycyrrhiza glabra extract as a hepatoprotective and antioxidant agent in fish.

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