Interference-resistant aptasensor with tetrahedral DNA nanostructure for profenofos detection based on the composites of graphene oxide and polyaniline

文献类型： 外文期刊

第一作者： Wang, Guanjie

作者： Wang, Guanjie;Dong, Haowei;Han, Jie;Zhang, Mei;Huang, Jingcheng;Sun, Jiashuai;Guan, Fukai;Shen, Zhen;Xu, Deyan;Sun, Xia;Guo, Yemin;Zhao, Shancang;Wang, Guanjie;Dong, Haowei;Han, Jie;Zhang, Mei;Huang, Jingcheng;Sun, Jiashuai;Guan, Fukai;Shen, Zhen;Xu, Deyan;Sun, Xia;Guo, Yemin;Zhao, Shancang;Wang, Guanjie;Dong, Haowei;Han, Jie;Zhang, Mei;Huang, Jingcheng;Sun, Jiashuai;Guan, Fukai;Shen, Zhen;Xu, Deyan;Sun, Xia;Guo, Yemin;Zhao, Shancang;Zhao, Shancang

作者机构：

关键词： Electrochemical aptasensor; Gold nanoparticles-tetrahedral DNA nano-structure; Graphene oxide and polyaniline; Profenofos

期刊名称：BIOELECTROCHEMISTRY （ 影响因子：5.76； 五年影响因子：5.368 ）

ISSN： 1567-5394

年卷期： 2022 年 148 卷

页码：

收录情况： SCI

摘要： In this work, an interference-resistant electrochemical aptasensor that could detect profenofos in vegetables was constructed based on complexes of graphene oxide and polyaniline (GO@PANI) and gold nanoparticles-tetrahedral DNA nanostructure (Au-TDN). Compared with a single chain aptamer, the tetrahedral DNA nano -structure is highly stable and allows the aptamer on this structure to stand in a highly ordered position on an electrode surface. Moreover, the AuNPs are biocompatible and can protect the activity of the aptamer, which can improve the assembly success rate of Au-TDN. Besides, the conductivity of PANI had been tremendously enhanced thanks to the existence of GO, which improved the dispersion of PANI. The GO@PANI was prepared by a chemical synthesis method, which had a large surface area and was able to adsorb many Au-TDN. Under optimal working parameters, the constructed aptasensor exhibited good electrochemical sensing performance with a detection limit of 10.50 pg/mL and a linear range of 1.0 x 10(2)-1.0 x 10(7) pg/mL. In addition, it was employed in detecting profenofos in vegetables with a good recovery rate of 90.41-116.37 %. More importantly, the aptasensor also has excellent stability and high selectivity. This study provides a promising method to avoid interference in the detection of profenofos by sensors.

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