Characterization of the antimicrobial activity and mechanism of the peptide Squ8 isolated from fermented mulberry leaves

文献类型： 外文期刊

第一作者： Xu, Zhuo

作者： Xu, Zhuo;Chen, Yaoyu;Wang, Lei;Xu, Zhuo;Li, Ruobing;Chen, Yaoyu;Yuan, Yin;Wang, Yongsheng;Wang, Yongsheng

作者机构：

关键词： Fermented mulberry leaves; Antimicrobial peptide; Antibacterial activity; Membrane disruption

期刊名称：BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS （ 影响因子：2.2； 五年影响因子：2.5 ）

ISSN： 0006-291X

年卷期： 2025 年 780 卷

页码：

收录情况： SCI

摘要： This study identifies a novel antimicrobial peptide, Squ8, from fermented mulberry leaves via LC-MS. The peptide (amino acid sequence RMGAGMAK, 820 Da) features an alpha-helical structure, +2 net charge, 50 % hydrophobicity, and antibacterial activity against Gram-negative/positive bacteria. Unlike many antimicrobial peptides that are easily inactivated under extreme temperatures or pH conditions, Squ8 retains its activity under such circumstances and has a low hemolysis rate, thus demonstrating excellent stability and safety. Additionally, it can target the genomic DNA of E.coli, exerting a unique multi-target mechanism that reduces the risk of drug resistance. These findings highlight Squ8 as a promising candidate for the development of antimicrobial drugs or novel food/feed additives, and provide a strategy to mitigate antibiotic abuse and drug resistance.

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