Multi-Functional Core-Shell Nanofibers for Wound Healing

文献类型： 外文期刊

第一作者： Li, Zhen

作者： Li, Zhen;Mei, Shunqi;Dong, Yajie;Li, Zhen;Dong, Yajie;She, Fenghua;Kong, Lingxue;Li, Zhen;Li, Puwang;Li, Yongzhen

作者机构：

关键词： core-shell nanofiber; drug delivery; co-axial centrifugal spinning; wound healing

期刊名称：NANOMATERIALS （ 影响因子：5.076； 五年影响因子：5.346 ）

ISSN：

年卷期： 2021 年 11 卷 6 期

页码：

收录情况： SCI

摘要： Core-shell nanofibers have great potential for bio-medical applications such as wound healing dressings where multiple drugs and growth factors are expected to be delivered at different healing phases. Compared to monoaxial nanofibers, core-shell nanofibers can control the drug release profile easier, providing sustainable and effective drugs and growth factors for wound healing. However, it is challenging to produce core-shell structured nanofibers with a high production rate at low energy consumption. Co-axial centrifugal spinning is an alternative method to address the above limitations to produce core-shell nanofibers effectively. In this study, a co-axial centrifugal spinning device was designed and assembled to produce core-shell nanofibers for controlling the release rate of ibuprofen and hEGF in inflammation and proliferation phases during the wound healing process. Core-shell structured nanofibers were confirmed by TEM. This work demonstrated that the co-axial centrifugal spinning is a high productivity process that can produce materials with a 3D environment mimicking natural tissue scaffold, and the specific drug can be loaded into different layers to control the drug release rate to improve the drug efficiency and promote wound healing.

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