Effect of 17 alpha-methyltestosterone (MT) on osmoregulatory responses and apoptosis in genetically improved farmed tilapia (GIFT), Oreochromis niloticus (L.)

文献类型： 外文期刊

第一作者： Zheng, Yao

作者： Zheng, Yao;Bing, Xuwen;Hu, Gengdong;Song, Chao;Qiu, Liping;Meng, Shunlong;Fan, Limin;Li Dan-dan;Chen, Jiazhang;Zheng, Yao;Bing, Xuwen;Chen, Jiazhang

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关键词： Aquatic pollution; Fish farming; Masculinisation; Nile tilapia

期刊名称：INDIAN JOURNAL OF EXPERIMENTAL BIOLOGY （ 影响因子：0.818； 五年影响因子：1.006 ）

ISSN： 0019-5189

年卷期： 2021 年 59 卷 6 期

页码：

收录情况： SCI

摘要： Androgenic compounds can affect osmoregulatory response and apoptosis in fish. In the present study, we exposed genetically improved farmed tilapia (GIFT) Oreochromis niloticus (L.) to 17 alpha-methyltestosterone (MT, 0.5 and 5 mg/L) for 7, 14 and 21 days for understanding the phenomenon. The activities of Na+/K+ ATPase (NKA) and Ca2+/Mg2+ ATPase (CMA) were measured in the gill, kidney and intestine to evaluate the change in osmoregulation of GIFT, and genotoxicity was also detected. Results showed that organic NKA were significantly decreased in 5 mg/L MT exposure groups. The intestine NKA was significantly increased (0.5 mg/L MT). MT exposures increased the CMA of kidney and intestine (0.5 mg/L), together with gill CMA (5 mg/L MT). The results of genotoxicity assay showed gill atplala and nkcc2 transcripts significantly increased, while intestine atplala and fxyd7 transcripts revealed significant increases for MT exposure groups. Caspases proteins demonstrated significant increases at 7th and 21st day, and their transcripts were enhanced in 0.5 mg/L MT exposure groups. The results have evidently demonstrated that chronic exposure of MT could result in organic osmoregulatory response and hepatic apoptosis in GIFT O. niloticus.

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