Antiviral Effect of pIFNLs against PEDV and VSV Infection in Different Cells

文献类型： 外文期刊

第一作者： Chen, Jing

作者： Chen, Jing;Jin, Ningyi;Chen, Jing;X, Wang;Li, Peiheng;Song, Lina;Jiang, Yuhang;Hao, Pengfei;Gao, Zihan;Zou, Wancheng;Jin, Ningyi;Li, Chang

作者机构：

关键词： pIFNLs; pIFN alpha; VSV-EGFP; PEDV; antiviral activity

期刊名称：INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES （ 影响因子：6.208； 五年影响因子：6.628 ）

ISSN：

年卷期： 2022 年 23 卷 17 期

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收录情况： SCI

摘要： Type III and type I interferon have similar mechanisms of action, and their different receptors lead to different distributions in tissue. On mucosal surfaces, type III interferon exhibits strong antiviral activity. Porcine epidemic diarrhea virus (PEDV) is an economically important enteropathogenic coronavirus, which can cause a high incidence rate and mortality in piglets. Here, we demonstrate that porcine interferon lambda 1 (pIFNL1) and porcine interferon lambda 3 (pIFNL3) can inhibit the proliferation of vesicular stomatitis virus with an enhanced green fluorescent protein (VSV-EGFP) in different cells, and also show strong antiviral activity when PEDV infects Vero cells. Both forms of pIFNLs were shown to be better than porcine interferon alpha (pIFN alpha), the antiviral activity of pIFNL1 is lower than that of pIFNL3. Therefore, our results provide experimental evidence for the inhibition of PEDV infection by pIFNLs, which may provide a promising treatment for the prevention and treatment of Porcine epidemic diarrhea (PED) in piglets.

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