Development and Immunoprotection of Bacterium-like Particle Vaccine against Infectious Bronchitis in Chickens
文献类型： 外文期刊
第一作者： Zhang, Pengju
作者： Zhang, Pengju;Qiao, Haiying;Hu, Nianzhi;Li, Xintao;Wang, Weixia;Zhang, Lichun;Yang, Tiantian;Cong, Yanlong;Sun, Yixue
作者机构：
关键词： infectious bronchitis virus; S1 subunit; bacterium-like particles; immunoprotective
期刊名称：VACCINES （ 影响因子：7.8； 五年影响因子：7.4 ）
ISSN：
年卷期： 2023 年 11 卷 8 期
页码：
收录情况： SCI
摘要： Infectious bronchitis (IB) is a major threat to the global poultry industry. Despite the availability of commercial vaccines, the IB epidemic has not been effectively controlled. The exploration of novel IBV vaccines may provide a new way to prevent and control IB. In this study, BLP-S1, a bacterium-like particle displaying the S1 subunit of infectious bronchitis virus (IBV), was constructed using the GEM-PA surface display system. The immunoprotective efficacy results showed that BLP-S1 can effectively induce specific IgG and sIgA immune responses, providing a protection rate of 90% against IBV infection in 14-day-old commercial chickens. These results suggest that BLP-S1 has potential for the development of novel vaccines with good immunogenicity and immunoprotection.
分类号：
- 相关文献
作者其他论文 更多>>
-
The Fermentation Quality, Antioxidant Activity, and Bacterial Community of Mulberry Leaf Silage with Pediococcus, Bacillus, and Wheat Bran
作者：Li, Jinzhuan;Zhang, Haosen;Yang, Tiantian;Abbas, Zaheer;Jiang, Xiaohan;Zhang, Rijun;Si, Dayong;Li, Guiming;Zhang, Heng
关键词：mulberry leaf; fermentation quality; antioxidant activity; bacterial community
-
Alpha-lipoic acid improves cryopreservation of rooster semen by reducing oxidative stress
作者：Chen, Xiaoxin;Liu, Jianqiang;Liu, Yi;Li, Xu;An, Dingjie;Liu, Xiaohui;Zhang, Lichun
关键词：alpha-lipoic acid; antioxidant capacity; semen freezing; rooster sperm ultramicrostructure
-
Decolorization and detoxication of malachite green by engineered Saccharomyces cerevisiae expressing novel thermostable laccase from Trametes trogii
作者：Song, Xiaofei;Shan, Yudong;Cao, Longyu;Zhong, Xiuwen;Wang, Xikai;Wang, Kun;Zhu, Tingheng;Gao, Yan;Wang, Weixia
关键词：Laccase; Saccharomyces erevisiae; Decolorization; Detoxication; Malachite Green
-
Hemagglutinin glycosylation pattern-specific effects: implications for the fitness of H9.4.2.5-branched H9N2 avian influenza viruses
作者：Sun, Yixue;Sun, Yixue;Zhu, Yanting;Sheng, Shouzhi;Guan, Zhenhong;Cong, Yanlong;Sun, Yixue;Zhu, Yanting;Sheng, Shouzhi;Guan, Zhenhong;Cong, Yanlong;Zhang, Pengju
关键词：Avian influenza; h9.4.2.5 branch; hemagglutinin; glycosylation; adaptive phenotype
-
The comparison of meat yield, quality, and flavor between small-tailed Han sheep and two crossbred sheep and the verification of related candidate genes
作者：Xiao, Cheng;Liu, Yu;Zhao, Wenjun;Liang, Yingjia;Cui, Chao;Yang, Shaoying;Fang, WenWen;Miao, Lisheng;Yuan, Zhiyu;Zhai, Bo;Zhao, Zhongli;Zhang, Lichun;Ma, Huihai;Jin, Haiguo;Cao, Yang;Xiao, Cheng;Xiao, Cheng;Zhao, Wenjun;Lin, Zihan
关键词：small-tailed Han sheep; crossbred sheep; meat yield; quality; volatile compound; PDK4 gene; TMEM273 gene
-
Inactivated Recombinant Rabies Virus Displaying the Nipah Virus Envelope Glycoproteins Induces Systemic Immune Responses in Mice
作者：Li, Zhengrong;Zhu, Yanting;Jin, Hongli;Yang, Songtao;Xia, Xianzhu;Cong, Yanlong;Yan, Feihu;Jin, Hongli;Wang, Qi;Zhao, Yongkun;Feng, Na;Wang, Tiecheng;Li, Nan;Yang, Songtao;Xia, Xianzhu
关键词：Nipah virus; envelope glycoproteins; recombinant rabies virus; immune response; vaccine
-
Long non-coding RNA NEAT1 promotes mouse granulosa cell proliferation and estradiol synthesis by sponging miR-874-3p
作者：Zhang, Pengju;Wang, Weixia;Tan, Chengcheng;Liu, Xiaohui;Li, Xintao;Zhang, Lichun;Gao, Jinliang;Lin, Shan;Lin, Guangyu;Li, Xintao;Zhang, Lichun
关键词：long non-coding RNA; nuclear-enriched abundant transcript 1; mouse granulosa cell; apoptosis; estradiol synthesis
