Circular RNA transcriptome across multiple tissues reveal skeletal muscle-specific circPSME4 regulating myogenesis

文献类型： 外文期刊

第一作者： Zeng, Mu

作者： Zeng, Mu;Yan, Shanying;Yang, Peng;Li, Qiaowei;Li, Jiju;Fan, Xinhao;Liu, Xiaoqin;Yao, Yilong;Wang, Wei;Chen, Ruipu;Han, Guohao;Yang, Yalan;Tang, Zhonglin;Yang, Peng;Tang, Zhonglin;Yang, Peng;Tang, Zhonglin;Zeng, Mu;Yan, Shanying;Yang, Peng;Li, Qiaowei;Li, Jiju;Fan, Xinhao;Liu, Xiaoqin;Yao, Yilong;Wang, Wei;Chen, Ruipu;Han, Guohao;Yang, Yalan;Tang, Zhonglin;Zeng, Mu;Yan, Shanying;Yang, Peng;Li, Qiaowei;Li, Jiju;Fan, Xinhao;Liu, Xiaoqin;Yao, Yilong;Wang, Wei;Chen, Ruipu;Han, Guohao;Yang, Yalan;Tang, Zhonglin;Li, Qiaowei

作者机构：

关键词： Pig; Multi-tissues; CircRNAs; Skeletal muscle; CircPSME4

期刊名称：INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES （ 影响因子：8.2； 五年影响因子：7.8 ）

ISSN： 0141-8130

年卷期： 2023 年 251 卷

页码：

收录情况： SCI

摘要： There are significant differences in meat production, growth rate and other traits between Western commercial pigs and Chinese local pigs. Comparative transcriptome approaches have identified many coding and non-coding candidate genes associated various traits. However, the expression and function of circular RNAs (circRNAs) in different pig tissues are largely unknown. In this study, we conducted a comprehensive analysis of the genomewide circRNA expression profile across ten tissues in Luchuan (a Chinese local breed) and Duroc (a Western commercial breed) pigs. We identified a total of 56,254 circRNAs, of which 42.9 % were not previously annotated. We found that 33.7 % of these circRNAs were differentially expressed. Enrichment analysis revealed that differentially expressed circRNAs might contribute to the phenotypic differentiation between Luchuan and Duroc pigs. We identified 538 tissue-specific circRNAs, most of which were specifically expressed in the brain and skeletal muscle. Competitive endogenous RNA network analysis suggested that skeletal muscle-specific circPSME4 was co-expressed with MYOD1 and targeted by ssc-miR-181d-3p. Functional analysis revealed that circPSME4 knockdown could promote the proliferation and differentiation of myoblasts. Together, our findings provide valuable resources of circRNAs for animal breeding and biomedical research. We demonstrated that circPSME4 is a novel regulator of skeletal muscle development.

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