文献类型： 外文期刊
第一作者： Fu, Yang
作者： Fu, Yang;Sun, Jie;Lian, Shizhen;Deng, Xiaoyu;Zhang, Lei;Yan, Xijun;Zhu, Yanzhu;Fu, Yang;Shao, Jikai;Yu, Hongguang
作者机构：
关键词： canine adenovirus type 1; silver fox; inactivated vaccine; immunogenicity; CAdV-1 F1301 strain
期刊名称：FRONTIERS IN VETERINARY SCIENCE （ 影响因子：3.471； 五年影响因子：3.821 ）
ISSN：
年卷期： 2022 年 9 卷
页码：
收录情况： SCI
摘要： Canine adenovirus type 1 (CAdV-1) is the etiologic agent of fox encephalitis. As with most viral agents, the best method of prevention is vaccination. In this study, the CAdV-1 strain F1301 strain was used to construct a new type 1 canine adenovirus inactivated vaccine candidate, and its safety and immunogenicity were evaluated in silver foxes. Next, animals were challenged and survival rates of animals vaccinated with either the commercially available or the current candidate vaccine were examined. The results confirmed that the inactivated CAdV-1 vaccine prepared in this study can effectively protect against challenge with virulent CAdV-1 in silver foxes, and the safety profile was improved relative to that of the commercial vaccine. This study confirmed that the fox CAdV-1 F1301 strain can be used as a platform for an inactivated CAdV-1 vaccine.
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