Multifunctional metal-organic frameworks-mediated colorimetric/ photothermal immunosensor for highly sensitivity detection of dibutyl phthalate

文献类型： 外文期刊

第一作者： Wang, Chen

作者： Wang, Chen;Zhang, Gao;Tang, Xiaoqian;Wang, Chen;Xiang, Chengyan;Zhang, Haoran;Zhang, Gao;Zhang, Qi;Li, Peiwu;Tang, Xiaoqian;Zhang, Qi;Li, Peiwu;Tang, Xiaoqian;Zhang, Qi;Li, Peiwu

作者机构：

关键词： Dibutyl phthalate; Monoclonal antibody; Metal-organic framework; Dual signal output; Lateral flow immunosensor

期刊名称：FOOD CHEMISTRY （ 影响因子：9.8； 五年影响因子：9.7 ）

ISSN： 0308-8146

年卷期： 2025 年 472 卷

页码：

收录情况： SCI

摘要： Dibutyl phthalate (DBP), a priority pollutant among phthalic acid esters (PAEs) exhibits significant reproductive and respiratory toxicity. In this study, a multifunctional metal-organic frameworks-mediated colorimetric/ photothermal immunosensor was established for the quantitative detection of DBP. Firstly, a highly sensitive and specific monoclonal antibody (mAb), designated 3A5, was prepared with a sensitivity IC50 value of 16.29 ng/mL. Secondly, a metal-organic framework material (ZrO2@C) was synthesized via a two-step pyrolysis process of UiO66. Subsequently, a multifunctional immunoprobe was prepared for the detection of DBP. Using ZrO2@C-based colorimetric and photothermal dual-signal immunosensor ensured the accuracy of the detection results, as the multiple of these signals effectively guaranteed the reliability of the results. The limit of detection (LOD) for the dual signal was 0.766 ng/mL (colorimetric signal) and 0.465 ng/mL (photothermal signal). In conclusion, this work presented a novel and feasible approach for the development of multifunctional nanomaterials for the fabrication of immunosensors.

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