Chemical fingerprinting and the biological properties of extracts from Fomitopsis pinicola

文献类型： 外文期刊

第一作者： Zhang, Zuo-Fa

作者： Zhang, Zuo-Fa;Wu, Chao;Wang, Mei;Chen, Jian-Fei;Lv, Guo-Ying

作者机构：

关键词： Fomitopsis pinicola; Antioxidant activity; Anticancer activity; UPLC-Triple-TOF-MS

期刊名称：ARABIAN JOURNAL OF CHEMISTRY （ 影响因子：6.0； 五年影响因子：5.9 ）

ISSN： 1878-5352

年卷期： 2023 年 16 卷 5 期

页码：

收录情况： SCI

摘要： This study investigated the in vitro antioxidant and anticancer properties of the Fomitop-sis pinicola extract (EMFP). The antioxidant activity of EFMP was analysed via free radical scav-enging (DPPH, ABTS and Hydroxyl radicals) assay and a protein oxidation assay. EFMP effectively scavenged free radicals and exhibited remarkable protection against protein oxidation. The proliferation of EMFP-treated HepG2 cells was remarkably decreased. EMFP effectively increased the reactive oxygen species (ROS) production, depleted the mitochondrial membrane potential (MMP) and promoted the apoptosis of HepG2 cells. In addition, EMFP increased the malondialdehyde (MDA) content and reduced the activities of SOD, CAT and GPx in HepG2 cells. Using UPLC-Triple-TOF-MS, 2 phenolic compounds and 14 triterpenes were identified. These compounds may be the primary contributors to the antioxidant and anticancer capacities of EMFP. Together, these findings highlight the possibility of exploiting EMFP for its desired pharmaceutical ingredients.(c) 2023 The Author(s). Published by Elsevier B.V. on behalf of King Saud University. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).

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