Functional analyses of inhibitor of apoptosis protein 1 (IAP1) of Antheraea pernyi multinucleocapsid nucleopolyhedrovirus (AnpeNPV) in viral replication and occlusion body production
文献类型： 外文期刊
第一作者： Zhao, Zhenjun
作者： Zhao, Zhenjun;Yue, Dongmei;Ye, Bo;Li, Peipei;Wang, Linmei;Zhang, Bo;Fan, Qi;Li, Wenli
作者机构：
关键词： Baculovirus; Inhibitor of apoptosis protein 1; Antheraea pernyi; Subcellular localization; Occlusion body production
期刊名称：JOURNAL OF INVERTEBRATE PATHOLOGY （ 影响因子：3.4； 五年影响因子：3.1 ）
ISSN： 0022-2011
年卷期： 2022 年 194 卷
页码：
收录情况： SCI
摘要： Inhibitor of apoptosis protein 1 (IAP1) of Antheraea pernyi multinucleocapsid nucleopolyhedrovirus (AnpeNPV) belongs to the baculovirus IAP1 type. The function of AnpeNPV-IAP1 in viral replication and occlusion body (OB) production remains unknown. In this study, we demonstrated that AnpeNPV-iap1 is a late gene. AnpeNPV-IAP1 mainly localizes to the nuclear ring zone and exhibits dynamic distribution in the cytoplasm and the virogenic stroma during AnpeNPV infection. AnpeNPV-IAP1 impacted the expression of a variety of viral genes at the very late phase of infection in Tn-Hi5 cells. The deletion of AnpeNPV-iap1 caused decreased expression levels of polyhedrin, morphological changes to OBs and reduced OB production in A. pernyi pupae, along with a lengthening of the lethal time of A. pernyi larvae. These results suggest that AnpeNPV-iap1 is involved in regulating viral gene expression, OB production and morphogenesis in A. pernyi.
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