Holothuria leucospilota polysaccharides alleviate liver injury via AMPK and NF-Kappa B signaling pathways in type 2 diabetic rats

文献类型： 外文期刊

第一作者： Zhao, Fuqiang

作者： Zhao, Fuqiang;Cao, Jun;Xia, Guanghua;Liu, Zhongyuan;Li, Chuan;Zhu, Kexue;Zhao, Qiancheng;Zhao, Qiancheng;Xia, Guanghua;Liu, Zhongyuan;Li, Chuan;Liu, Qibing

作者机构：

关键词： Holothuria leucospilota; Polysaccharide; Type 2 diabetes mellitus; Liver injury; Oxidative stress; Inflammation

期刊名称：JOURNAL OF FUNCTIONAL FOODS （ 影响因子：4.451； 五年影响因子：4.908 ）

ISSN： 1756-4646

年卷期： 2021 年 85 卷

页码：

收录情况： SCI

摘要： The study evaluated the beneficial effects of orally administered Holothuria leucospilota polysaccharides (HLP) on liver injury in diabetic rats. The results showed that HLP regulated liver glycogen, glycosylated serum protein, aspartate aminotransferase (AST) and alanine aminotransferase (ALT) levels. Simultaneously, HLP significantly reduced lipid accumulation in livers of diabetic rats (P < 0.05). In addition, HLP exerted anti-oxidant and antiinflammatory activities, together with repaired histological impairment of liver in diabetes. Moreover, HLP downregulated the mRNA and protein expression of inhibitors of nuclear factor kappa B kinase beta (IKK beta), nuclear factor kappa B P65 (NF-kappa B P65) and glycogen synthase kinase 3 beta (GSK3 beta), while upregulated the expression of nuclear factor erythroid 2-related factor 2 (Nrf2), heme oxygenase-1 (HO-1) and AMP-activated protein kinase alpha (AMPK alpha) in the liver. These findings suggested that HLP improved liver injury via AMPK and NF-kappa B related signaling pathways in type 2 diabetic rats.

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