Breeding of 'DND358': A new soybean cultivar for processing soy protein isolate with a hypocholesterolemic effect similar to that of fenofibrate

文献类型： 外文期刊

第一作者： Song, Bo

作者： Song, Bo;Qiu, Zhendong;Li, Mingxue;Luo, Tingting;Xu, Pengfei;Zhang, Shuzhen;Liu, Shanshan;Wu, Qi;Krishnan, Hari B.;Krishnan, Hari B.;Wu, Junjiang

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关键词： Soybean cultivar 'DND358'; Soy protein isolate beverage powder; Hypocholesterolemic effect; Fenofibrate

期刊名称：JOURNAL OF FUNCTIONAL FOODS （ 影响因子：5.223； 五年影响因子：5.178 ）

ISSN： 1756-4646

年卷期： 2022 年 90 卷

页码：

收录情况： SCI

摘要： Soy proteins have hypocholesterolemic effects (HCE). Here, we developed a soybean cultivar 'DND358', which is superior for processing hypocholesterolemic soy protein isolate beverage powder (DND358-SPI). 'DND358' carries four recessive null alleles for the alpha subunit of 7S globulin and the G1, G2, and G4 subunits of 11S globulin (tetra null), was selected from a population derived from a three-way cross. The tetra null mutation resulted in a compensatory increase in the alpha & PRIME; subunit level and arginine content. The oral administration (300 mg/kg/day) of DND358-SPI processed from 'DND358' significantly decreased the fatty liver symptoms and hepatic lipid accumulation; reduced the hepatic total cholesterol (TC), triacylglycerol (TG) levels and atherogenic index (AI) value, in rats fed a high-cholesterol diet. Conversely, DND358-SPI administration markedly elevated high-density lipoprotein cholesterol levels, to values significantly higher to those fed on fenofibrate (FF, 30 mg/kg/day), a hypocholesterolemic drug. The HCE of DND358-SPI were similar to that of FF.

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