Multi-Omics Analysis Reveals the Regulatory Mechanism of Different Probiotics on Growth Performance and Intestinal Health of Salmo trutta (S. trutta)

文献类型： 外文期刊

第一作者： Chen, Mengjuan

作者： Chen, Mengjuan;Wang, Zhitong;He, Hui;He, Wenjia;Zhang, Zihao;Sun, Shuaijie;Wang, Wanliang;Chen, Mengjuan;Wang, Zhitong;He, Hui;He, Wenjia;Zhang, Zihao;Sun, Shuaijie;Wang, Wanliang;Wang, Wanliang

作者机构： Tibet Acad Agr & Anim Husb Sci, Inst Fishery Sci, Lhasa 850032, Peoples R China;Henan Agr Univ, Coll Anim Sci & Technol, Zhengzhou 450046, Peoples R China;Indigenous Fish Breeding & Utilizat Engn Res Ctr X, Lhasa 850032, Peoples R China;Key Lab Fishery & Germplasm Resources Utilizat Xiz, Lhasa 850032, Peoples R China

关键词： Salmo trutta; probiotics; gut microbiome; gut metabolome; intestinal function

期刊名称：MICROORGANISMS （ 2023影响因子：4.1； 五年影响因子：4.5 ）

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年卷期： 2024 年 12 卷 7 期

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收录情况： SCI

摘要： Probiotics play an important role in animal production, providing health benefits to the host by improving intestinal microbial balance. In this study, we added three different probiotics, Saccharomyces cerevisiae (SC), Bacillus licheniformis (BL), and lactic acid bacteria (LAB), and compared them with the control group (CON), to investigate the effects of probiotic supplementation on growth performance, gut microbiology, and gut flora of S. trutta. Our results showed that feeding probiotics improved the survival, growth, development, and fattening of S. trutta. Additionally, probiotic treatment causes changes in the gut probiotic community, and the gut flora microorganisms that cause significant changes vary among the probiotic treatments. However, in all three groups, the abundance of Pseudomonas, Acinetobacter, and Rhizophagus bacterial genera was similar to that in the top three comparative controls. Furthermore, differences in the composition of intestinal microbiota among feed types were directly associated with significant changes in the metabolomic landscape, including lipids and lipid-like molecules, organic acids and derivatives, and organoheterocyclic compounds. The probiotic treatment altered the gut microbiome, gut metabolome, and growth performance of S. trutta. Using a multi-omics approach, we discovered that the addition of probiotics altered the composition of gut microbiota, potentially leading to modifications in gut function and host phenotype. Overall, our results highlight the importance of probiotics as a key factor in animal health and productivity, enabling us to better evaluate the functional potential of probiotics.

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