Petunidin-3-O-[rhamnopyranosyl-(trans-p-coumaroyl)]-5-O-(β-D-glucopyranoside), the main anthocyanin from the fruits of Lycium ruthenicum murray, enhances the lifespan of Caenorhabditis elegans by activating DAF-16 and improving the gut microbiota
文献类型： 外文期刊
第一作者： Zhang, Kangzhi
作者： Zhang, Kangzhi;Zhu, Jiahao;Liu, Peiyun;Guo, Renpeng;Zeng, Xiaoxiong;Yan, Yamei;Mi, Jia;Lu, Lu;Cao, Youlong;Yan, Yamei;Mi, Jia;Lu, Lu;Cao, Youlong
作者机构：
关键词： Lycium ruthenicum murray; Caenorhabditis elegans; Lifespan; Antioxidant; Resistance; DAF-16; Intestinal microbiota
期刊名称：FOOD BIOSCIENCE （ 影响因子：4.8； 五年影响因子：5.1 ）
ISSN： 2212-4292
年卷期： 2024 年 61 卷
页码：
收录情况： SCI
摘要： Research on anti -aging activity primarily focuses on crude extracts of anthocyanins, while relatively less attention has been given to anthocyanin monomers. This study was focused on exploring the anti -aging properties of the main anthocyanin monomer, petunidin-3- O -[rhamnopyranosyl-( trans - p -coumaroyl)]-5- O -( beta-D-glu- copyranoside) (P3G), from the fruits of Lycium ruthenicum Murray. The effects of P3G on stress endurance, lifespan, and gut microbiota in Caenorhabditis elegans were investigated. It was found that P3G significantly extended the mean lifespan by 19.50%, enhanced fitness through increased motility (30.39%) and pharyngeal pumping (18.33%), and reduced lipofuscin accumulation by 43.61% while maintaining fecundity. P3G prolonged lifespan by 20.13% and 18.82% during oxidative and heat stress, correspondingly. This effect was attributed to the activation of stress -related genes and the antioxidant system. The transcriptome results showed the enrichment in the longevity pathway and biosynthesis pathway of nematodes. The prominent role of the DAF-16 pathway was highlighted, as P3G enhanced the expression of daf-16 gene and downstream genes ( sod -2 , sod -3 , and mlt-1 ), promoting nuclear accumulation of DAF-16. Moreover, modifications in the gut microbiota induced by P3G played a role in its anti -aging properties by governing gut microbial composition. Overall, P3G appeared to contribute to promoting the health of nematodes and might help delay their aging to some extent.
分类号：
- 相关文献
作者其他论文 更多>>
-
Oral delivery of miR-146a-5p overexpression plasmid-loaded Pickering double emulsion modulates intestinal inflammation and the gut microbe
作者：Zhu, Jiahao;Fan, Yaotian;Yang, Songfeng;Qin, Mengran;Luo, Junyi;Chen, Ting;Sun, Jiajie;Zhang, Yongliang;Xi, Qianyun;Chen, Xingping
关键词：Inflammatory injury; miR-146a-5p; Pickering double emulsion; Intestinal homeostasis; Lactobacillus reuteri
-
Anthocyanin biosynthesis in goji berry is inactivated by deletion in a bHLH transcription factor LrLAN1b promoter
作者：Li, Tingting;Wang, Jingjin;Zhang, Zihan;Qin, Huan;Tang, Lin;Fan, Yunfang;Yin, Yue;Dai, Guoli;Cao, Youlong;Fan, Yunfang;Yin, Yue;Dai, Guoli;Cao, Youlong
关键词：
-
2-O-beta-D-Glucopyranosyl-L-ascorbic acid, an ascorbic acid derivative isolated from the fruits of Lycium barbarum L., ameliorates high fructose-induced neuroinflammation in mice: involvement of gut microbiota and leaky gutWei
作者：Dong, Wei;Peng, Yujia;Chen, Guijie;Xie, Zhiyong;Xu, Weiqi;Zhou, Wangting;Sun, Yi;Zeng, Xiaoxiong;Mi, Jia;Lu, Lu;Cao, Youlong;Yan, Yamei
关键词：Neuroinflammation; Gut microbiota; Leaky gut; Lipopolysaccharide; Fecal microbiome transplantation; 2O-beta-D-Glucopyranosyl-L-ascorbic acid
-
Effects of Spinach Extract and Licorice Extract on Growth Performance, Antioxidant Capacity, and Gut Microbiota in Weaned Piglets
作者：Zhu, Jiahao;Lian, Jincong;Deng, Haibin;Luo, Junyi;Chen, Ting;Sun, Jiajie;Zhang, Yongliang;Xi, Qianyun;Yang, Yongan;Liu, Pingxiang
关键词：weaned piglet; spinach extract; licorice extract; growth performance; antioxidant capacity; gut microbiota
-
An alfalfa MYB-like transcriptional factor MsMYBH positively regulates alfalfa seedling drought resistance and undergoes MsWAV3-mediated degradation
作者：Shi, Kun;Liu, Jia;Dong, Hongbin;Zhang, Jinli;Wei, Yuanhong;Zhou, Le;Wang, Shaopeng;Zhu, Jiahao;Wang, Zan;Liang, Huan;Cao, Mingshu;Jones, Chris S.;Ma, Dongmei
关键词：alfalfa; drought resistance; E3 ubiquitin ligase; MsMYBH; MsWAV3; MYB-like transcriptional factor
-
In vivo absorption and fecal excretion of polysaccharides from the fruits of Lycium barbarum L. in rats through fluorescence labeling
作者：Zhou, Wangting;Kan, Xuhui;Dong, Wei;Sun, Yi;Zeng, Xiaoxiong;Yan, Yamei;Mi, Jia;Lu, Lu;Cao, Youlong;Wang, Wei
关键词：Lycium barbarum polysaccharides; Fluorescence labeling; Absorption
-
Anthocyanins from Lycium ruthenicum Murray Prevent High-Fat Diet-Induced Obesity in Female Mice via Gut Microbiota-Related Bile Acids Metabolism
作者：Li, Hui;Zhang, Meng;Tan, Tingting;Li, Shiying;Ran, Linwu;Li, Hui;Zhang, Meng;Tan, Tingting;Li, Shiying;Ran, Linwu;Mi, Jia;Lu, Lu;Yan, Yamei
关键词：Lycium ruthenicum Murray; female obesity; gut microbiota; bile acid metabolism
