Metabolomic analysis of honey bees (Apis mellifera) response to carbendazim based on UPLC-MS

文献类型： 外文期刊

第一作者： Chen, Heng

作者： Chen, Heng;Wang, Kang;Xu, Hao;Liu, Yibing;Lin, Zheguang;Ji, Ting;Ji, Wenna;Wang, Shuang;Wang, Zhi;Gao, Fuchao

作者机构：

关键词： Metabolomics; Honey bee; Fungicide; Carbendazim

期刊名称：PESTICIDE BIOCHEMISTRY AND PHYSIOLOGY （ 影响因子：4.966； 五年影响因子：4.591 ）

ISSN： 0048-3575

年卷期： 2021 年 179 卷

页码：

收录情况： SCI

摘要： Pesticides are one of the main causes of colony losses globally, posing a huge threat to the beekeeping industry. The fungicide carbendazim is commonly used on many crops worldwide, but the effects of fungicides on honey bees have received less attention than those of insecticides. Previous studies have shown that sublethal doses of carbendazim hinder growth and development and may destabilize and impede the development of honey bee colonies. The metabolome closely reflects brain activity at the functional level, allowing the effects of compounds such as fungicides to be investigated. Here, we established a model of carbendazim-treated honey bees, Apis mellifera, and used metabolomic approaches to better understand the effect of carbendazim on bee metabolic profiles. The results showed that 112 metabolites were significantly affected in carbendazim-treated bees compared to the control. Metabolites associated with energy and amino acid metabolism showed high abundance and were enriched for a wide range of pathways. In addition, the down-regulation of Aflatoxin B1exo-8,9epoxide-GSH and glycerol diphosphate showed that carbenazim may affect the detoxification and immune system of honey bees. These results provide new insights into the interaction between fungicides and honey bees.

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