Exploring the intricacies of antimicrobial resistance: Understanding mechanisms, overcoming challenges, and pioneering innovative solutions

文献类型： 外文期刊

第一作者： Ul Haq, Shahbaz

作者： Ul Haq, Shahbaz;Danmei, Huang;Aleem, Muhammad Tahir;Gao, Fenfei;Ling, Wang;Aqib, Amjad Islam;Fatima, Mahreen;Ahmad, Saad

作者机构：

关键词： Antimicrobial resistance; Multidrug-resistant bacteria; Precision medicine; Antibiotic crisis; Innovative therapies; Global health

期刊名称：EUROPEAN JOURNAL OF PHARMACOLOGY （ 影响因子：4.7； 五年影响因子：4.7 ）

ISSN： 0014-2999

年卷期： 2025 年 998 卷

页码：

收录情况： SCI

摘要： Antimicrobial resistance (AMR) poses a growing global threat. This review examines AMR from diverse angles, tracing the story of antibiotic resistance from its origins to today's crisis. It explores the rise of AMR, from its historical roots to the urgent need to counter this escalating menace. The review explores antibiotic classes, mechanisms, resistance profiles, and genetics. It details bacterial resistance mechanisms with illustrative examples. Multidrug-resistant bacteria spotlight AMR's resilience. Modern AMR control offers hope through precision medicine, stewardship, combination therapy, surveillance, and international cooperation. Converging traditional and innovative treatments presents an exciting frontier as novel compounds seek to enhance antibiotic efficacy. This review calls for global unity and proactive engagement to address AMR collectively, emphasizing the quest for innovative solutions and responsible antibiotic use. It underscores the interconnectedness of science, responsibility, and action in combatting AMR. Humanity faces a choice between antibiotic efficacy and obsolescence. The call is clear: unite, innovate, and prevail against AMR.

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