QuEChERS with Magnetic Hydrophilic-Lipophilic Balanced Adsorbent and Its Application in Multi-Class Veterinary Residues in Milk by Ultra High-Performance Liquid Chromatography-Tandem Mass Spectrometry

文献类型： 外文期刊

第一作者： Liu, Hongcheng

作者： Liu, Hongcheng;Lin, Tao;Lin, Xin;Shao, Jinliang;Li, Qiwan;Liu, Hongcheng;Lin, Tao;Lin, Xin;Shao, Jinliang;Li, Qiwan;Liu, Hongcheng;Lin, Tao;Lin, Xin;Shao, Jinliang;Li, Qiwan

作者机构：

关键词： UHPLC-MS-MS;Fe3O4@C-HLB adsorbent;Multi-class veterinary residues

期刊名称：CHROMATOGRAPHIA （ 影响因子：2.044； 五年影响因子：1.725 ）

ISSN： 0009-5893

年卷期： 2018 年 81 卷 2 期

页码：

收录情况： SCI

摘要： Using magnetic hydrophilic-lipophilic balanced adsorbent (HLB), with divinylbenzene n-vinylpyrrolidone polymer as monomers and Fe3O4@C nanoparticles as magnetic material, a modified quick, easy, cheap, effective, rugged and safe (QuEChERS) method is proposed for veterinary residue analysis in milk. The magnetic Fe3O4@C-HLB adsorbent was fabricated via simple co-mixing method based on an "aggregate wrap" mechanism, which enabled magnetic solid-phase extraction. Thus, the resultant material can be separated from the solvent rapidly and conveniently by a magnet. The residues of regulatory interest in milk include beta-lactams, aminoglyside, and macrolides. The analytes were quantified by ultra high-performance liquid chromatography coupled to an electrospray ionization tandem mass spectrometer operating in multiple reaction monitoring modes. The decision limit (CC alpha) was 0.1-0.8 A mu g/L, and the detection capability (CC beta) was 0.2-2 A mu g/L. The method was accurate with recoveries ranging from 70.5 to 98%. Good intra-precision and intermediate precision were obtained with RSD better than 10%.

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