Anti-inflammatory effects of a methanolic extract of Castanea seguinii Dode in LPS-induced RAW264.7 macrophage cells

文献类型： 外文期刊

第一作者： Lim, Yourim

作者： Lim, Yourim;Park, Ji-Won;Kwon, Ok-Kyoung;Lee, Jae-Won;Lee, Han-Sol;Ahn, Kyung-Seop;Lim, Yourim;Lee, Han-Sol;Han, Sang-Bae;Lee, Sangwoo;Choi, Sangho;Li, Wanyi;Jin, Hang

作者机构：

关键词： Castanea seguinii;anti-inflammatory;RAW264;7;lipopolysaccharide;nuclear factor-B;mitogen-activated protein kinase

期刊名称：INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE （ 影响因子：4.101； 五年影响因子：4.084 ）

ISSN： 1107-3756

年卷期： 2018 年 41 卷 1 期

页码：

收录情况： SCI

摘要： Castanea extracts are known to have antioxidant properties and are used as a traditional medicine in China and Asia. However, the biological activity of Castanea seguinii Dode has remained to be fully elucidated. The present study investigated the anti-inflammatory effects of a Castanea seguinii Dode methanolic extract (CSME) on lipopolysaccharide-induced RAW264.7 macrophage cells. CSME inhibited the production of nitric oxide (NO) and the expression of inducible NO synthase. It also suppressed the production of the pro-inflammatory cytokines inteleukin-6 and tumor necrosis factor-, as well as chemokine monocyte chemoattractant protein 1. In addition, CSME inhibited nuclear factor-B (NF-B) and mitogen-activated protein kinase (MAPK) signaling, while also downregulating transcription factor activator protein-1. Furthermore, CSME increased heme oxygenase 1 through the upregulation of NF (erythroid-derived 2)-like-2 (Nrf-2), which directly or indirectly affects inflammation. It also increased the phosphorylation of 5-adenosine monophosphate-activated protein kinase (AMPK). In conclusion, CSME was demonstrated to exert its anti-inflammatory activities through the inhibition of the NF-B and the MAPK signaling pathways, as well as the activation of Nrf-2 and AMPK. These results indicated that CSME may be a promising for development as a commercial anti-inflammatory medicine.

分类号：

  • 相关文献

[1]Rhizosphere isoflavones (daidzein and genistein) levels and their relation to the microbial community structure of mono-cropped soybean soil in field and controlled conditions. Guo, Zhong-Yuan,Kong, Chui-Hua,Wang, Jing-Guo,Wang, Yu-Feng.

[2]Cellular and ultrastructural changes in the seedling roots of upland rice (Oryza sativa) under the stress of two allelochemicals from Ageratina adenophora. Wan, Fang-Hao,Guo, Jian-Ying,Liu, Wan-Xue,Yang, Guo-Qing.

[3]One new flavonoid from Solanum rostratum. Wang, Hui-min,Cao, Ao-cheng,Zhang, Chao-xian,Wei, Shou-hui,Ling, Tie-jun. 2017

[4]5,6,7,8-Tetrahydro-2-(2-phenylethyl)chromones from artificial agarwood of Aquilaria sinensis and their inhibitory activity against acetylcholinesterase. Mei, Wen-Li,Kong, Fan-Dong,Li, Wei,Yuan, Jing-Zhe,Dai, Hao-Fu,Liao, Ge.

[5]A Study of 2,3,7,8-Tetrachlorodibenzo-p-dioxin Induced Liver Injury in Jian Carp (Cyprinus carpio var. Jian) Using Precision-Cut Liver Slices. Du, Jin-Liang,Cao, Li-Ping,Yin, Guo-Jun,Du, Jin-Liang,Cao, Li-Ping,Yin, Guo-Jun,Liu, Ying-Juan,Jia, Rui,Yin, Guo-Jun.

[6]Recombinant TB10.4 of Mycobacterium bovis induces cytokine production in RAW264.7 macrophages through activation of the MAPK and NF-kappa B pathways via TLR2. Liu, Shuqing,Jia, Hong,Hou, Shaohua,Zhang, Gaimei,Xin, Ting,Yuan, Weifeng,Guo, Xiaoyu,Li, Ming,Wu, Jing,Zhu, Hongfei,Li, Hegang,Li, Hegang,Gao, Xintao. 2014

[7]Cloning and analysis of the soybean MEKK gene. Sha, A. -H.,Ba, H. -P.,Shan, Z. -H.,Chen, H. -F.,Chen, S. -L.,Qiu, D. -Z.,Zhou, X. -A.,Sha, A. -H.,Chen, Y. -H.. 2015

[8]The Role of Radical Burst in Plant Defense Responses to Necrotrophic Fungi. Kulye, Mahesh S.,Liu Hua,Qiu De-wen. 2012

[9]Selenium Inhibits LPS-Induced Pro-inflammatory Gene Expression by Modulating MAPK and NF-kappa B Signaling Pathways in Mouse Mammary Epithelial Cells in Primary Culture. Zhang, Wen,Wang, Tiancheng,Jiang, Haichao,Guo, Mengyao,Zhou, Ershun,Sun, Yong,Yang, Zhengtao,Cao, Yongguo,Zhang, Naisheng,Zhang, Runxiang,Xu, Shiwen. 2014

[10]Isolation and characterization of an oilseed rape MAP kinase BnMPK3 involved in diverse environmental stresses. Yu, SW,Zhang, LD,Zuo, KJ,Tang, DQ,Tang, KX.

[11]Expression Profiling of Mitogen-Activated Protein Kinase Genes Reveals Their Evolutionary and Functional Diversity in Different Rubber Tree (Hevea brasiliensis) Cultivars. Jin, Xiang,Zhu, Liping,Yao, Qi,Meng, Xueru,Ding, Guohua,Wang, Dan,Tong, Zheng,Wang, Xuchu,Jin, Xiang,Zhu, Liping,Xie, Quanliang,Tao, Chengcheng,Yu, Li,Li, Hongbin,Wang, Xuchu. 2017

[12]Identification of six mitogen-activated protein kinase (MAPK) genes in banana (Musa acuminata L. AAA group, cv. Cavendish) under infection of Fusarium Oxysporum f. sp cubense Tropical Race 4. Wang, Zhuo,Jia, Caihong,Li, Jianpin,Xu, Biyu,Jin, Zhiqiang,Jin, Zhiqiang.

[13]The anti-inflammatory effect of the SOCC blocker SK&F 96365 on mouse lymphocytes after stimulation by Con A or PMA/ionomycin. Ye, Yanxia,Zhang, Yaxing,Lu, Xiaoyu,Huang, Xiuyan,Zeng, Xiangfeng,Zeng, Yaoying,Lu, Xiaoyu,Lai, Xinqiang. 2011

[14]Egg-Derived Peptide IRW Inhibits TNF-alpha-Induced Inflammatory Response and Oxidative Stress in Endothelial Cells. Chakrabarti, Subhadeep,Jiang, Yanyan,Davidge, Sandra T.,Chakrabarti, Subhadeep,Jiang, Yanyan,Davidge, Sandra T.,Chakrabarti, Subhadeep,Jiang, Yanyan,Davidge, Sandra T.,Huang, Wuyang,Majumder, Kaustav,Wu, Jianping,Huang, Wuyang. 2010

[15]Inhibitory Effects of 4 '-Demethylnobiletin, a Metabolite of Nobiletin, on 12-O-Tetradecanoylphorbol-13-acetate (TPA)-Induced Inflammation in Mouse Ears. Wu, Xian,Song, Mingyue,Rakariyatham, Kanyasiri,Zheng, Jinkai,Wang, Minqi,Xu, Fei,Gao, Zili,Xiao, Hang,Xiao, Hang,Zheng, Jinkai.

[16]Lonicera japonica Thunb.: Ethnopharmacology, phytochemistry and pharmacology of an important traditional Chinese medicine. Shang, Xiaofei,Li, Maoxing,Li, Maoxing,Ding, Hong,Shang, Xiaofei,Pan, Hu,Miao, Xiaolou. 2011

[17]Ethnobotany, phytochemistry and pharmacology of the genus Caragana used in traditional Chinese medicine. Meng, Qiuxia,Roubin, Rebecca H.,Hanrahan, Jane R.,Meng, Qiuxia,Niu, Yu,Niu, Xiwu. 2009

[18]UPLC-Q-Exactive Orbitrap/MS-Based Lipidomics Approach To Characterize Lipid Extracts from Bee Pollen and Their in Vitro Anti-Inflammatory Properties. Li, Qiangqiang,Liang, Xinwen,Xue, Xiaofeng,Wang, Kai,We, Liming,Li, Qiangqiang,Liang, Xinwen,Xue, Xiaofeng,Wang, Kai,We, Liming,Li, Qiangqiang,Liang, Xinwen,Xue, Xiaofeng,Wang, Kai,Zhao, Liang,Zhang, Zhongyin.

[19]Identification of bioactives from Astragalus chinensis L.f. and their antioxidant, anti-inflammatory and anti-proliferative effects. Hu, Ting,Hu, Ting,Liu, Qi-Mei,He, Xiao-Wei,Jiang, Jian-Guo,Huang, Fei,Zhang, Ming-Wei.

[20]Expression of beta-defensins in intestines of chickens injected with vitamin D-3 and lipopolysaccharide. Lu, L.,Zhang, L.,Liu, X. Q.,Li, D. Y.,Zhao, X. L.,Liu, Y. P.,Li, S. M.. 2015

作者其他论文 更多>>

微信小程序