Development of natural perfume as potential fungicide candidates: construction and biological evaluation of vanillin analogs bearing the 1,3,4-oxadiazole/1,3-thiazolidin-4-one fragments

文献类型： 外文期刊

第一作者： Zhang, Cheng-Ran

作者： Zhang, Cheng-Ran;Wei, Si-Qi;Zhi, Xiao-Yan;Shi, Hong-Cheng;Liang, Jing;Hao, Xiao-Juan;Cao, Hui;Yang, Chun

作者机构：

关键词： Natural perfume; vanillin; 1,3,4-oxadiazole; 1,3-thiazolidin-4-one; antifungal activity

期刊名称：JOURNAL OF ASIAN NATURAL PRODUCTS RESEARCH （ 影响因子：1.7； 五年影响因子：1.7 ）

ISSN： 1028-6020

年卷期： 2024 年

页码：

收录情况： SCI

摘要： Two series of vanillin derivatives containing 1,3,4-oxadiazole and 1,3-thiazolidin-4-one scaffolds were prepared and evaluated for their antifungal activity. The results revealed that compounds 6j (29.73 mu g/ml) and 7a (38.15 mu g/ml) displayed excellent inhibitory activity against the spore of Fusarium solani. The inhibitory activity of compound 7d (10.53 mu g/ml) against the spore of Alternaria solani was more than 42-fold that of vanillin. Compound 7a (37.54 mu g/ml) showed better antifungal activity against the spore of B. cinerea than positive controls. The cytotoxicity assay confirmed that compounds 6k, 7a, and 7d showed good selectivity and less toxicity to normal mammalian cells.
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