Mixture toxicity of cadmium and acetamiprid to the early life stages of zebrafish (Danio rerio)

文献类型： 外文期刊

第一作者： Hu, Guixian

作者： Hu, Guixian;Wang, Hao;Wan, Yujie;Zhu, Jiahong;Li, Xue;Wang, Qiang;Wang, Yanhua;Shi, Haiyan

作者机构：

关键词： Mixture effect; Aquatic toxicology; Toxic mechanism; Zebrafish

期刊名称：CHEMICO-BIOLOGICAL INTERACTIONS （ 影响因子：5.168； 五年影响因子：4.924 ）

ISSN： 0009-2797

年卷期： 2022 年 366 卷

页码：

收录情况： SCI

摘要： Aquatic organisms are often exposed to contaminants that occur in the natural environment. Nevertheless, the toxic effects of chemical combinations on aquatic animals and their underlying toxic mechanisms for dealing with such exposures are still not fully understood. In this study, we investigated the combined effects of cadmium (Cd) and acetamiprid (ACE) on zebrafish (Danio rerio) using various endpoints. Cd exhibited a 96-h LC50 value of 4.77 mg a.i. L-1 against zebrafish embryos, which was lower than that of ACE (152.6 mg a.i. L-1). In contrast, the 96-h LC50 value of the mixture of Cd and ACE was 157.4 mg a.i. L-1. The mixture of Cd and ACE had a synergetic effect on the organisms. The activities of T-SOD, POD, and CarE were significantly changed in most exposures compared with the control group. In addition, five genes (TR alpha, crh, Tnf, IL, and P53) involved in oxidative stress, cellular apoptosis, the immune system, and the endocrine system exhibited more remarkable changes when exposed to chemical mixtures relative to their individual counterparts, demonstrating variations in the cellular and mRNA expression levels induced by the mixture exposure of ACE and Cd during the embryonic development of zebrafish. Therefore, these results indicated that the combined pollution of ACE and Cd could be a potentially hazardous factor, and further investigation is necessary for the safety evaluation and application of ACE. Moreover, further investigation on the combined toxicities of various chemicals must be performed to determine the chemical mixtures with synergistic responses.

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