文献类型： 外文期刊
第一作者： Li, Linfang
作者： Li, Linfang;Li, Linfang;Zhao, Jingzhuang;Shao, Yizhi;Lu, Tongyan;Xu, Liming;Zhao, Jingzhuang;Shao, Yizhi;Lu, Tongyan;Xu, Liming;Ma, Jie
作者机构： Univ Shanghai Ocean Univ, Coll Fisheries & Life Sci, Shanghai, Peoples R China;Chinese Acad Fishery Sci, Heilongjiang River Fisheries Res Inst, Dept Aquatic Anim Dis & Control, Harbin, Peoples R China;Key Lab Aquatic Anim Dis & Immune Technol Heilongj, Harbin, Peoples R China;Univ Idaho, Dept Fish & Wildlife Sci, Moscow, ID USA
关键词： MK-0608; Antiviral compound; IPNV; RdRp; Rainbow trout
期刊名称：FISH & SHELLFISH IMMUNOLOGY （ 2023影响因子：4.1； 五年影响因子：4.2 ）
ISSN： 1050-4648
年卷期： 2024 年 151 卷
收录情况： SCI
摘要： Infectious pancreatic necrosis virus (IPNV) is an important pathogen that is threatening the worldwide salmon and trout industry. But there is no therapeutic drug available for now. In this study, we demonstrate that MK0608 is highly efficient against IPNV and low cytotoxic, with a 50 % effective concentration (EC50) of 0.20 mu M and selectivity index (SI) of about 268. Time of addition assay illustrated that MK-0608 targeted the early stage of IPNV life cycle. Furthermore, we found that MK-0608 blocked IPNV attachment on the premise of sufficient pre-incubation time but MK-0608 did not influence viral internalization and release. MK-0608 could inhibit IPNV genome synthesis, and combination with ribavirin enhanced the inhibition effect, which might be functional via binding to IPNV RNA dependent RNA polymerase (RdRp), which was predicted by using molecular docking methods. In vivo test showed that IPNV was extremely suppressed in the rainbow trout (Oncorhynchus mykiss) with one single dose of MK-0608, and the higher dosage of 50 mg/kg could cause 3 log decrease of IPNV loads in fish tissues.
- 相关文献
作者其他论文 更多>>
-
Integrated metabolome and transcriptome analysis revealed color formation in purple leaf mustard ( Brassica juncea)
作者：Di, Hongmei;Zhao, Yatian;Zhou, Aolian;Yu, Xuena;Huang, Huanhuan;Tang, Yi;Li, Huanxiu;Zhang, Fen;Huang, Zhi;Sun, Bo;Chen, Zhifeng;Ma, Jie;Liu, Duchen;Escalona, Victor Hugo;Qian, Guiping
关键词：Mustard; Flavonoids; Anthocyanin; Photosynthesis; Transcription factors
-
Combination of light quality and melatonin regulates the quality in mustard sprouts
作者：Zhou, Aolian;Tang, Jiayi;Li, Ying;Yu, Xuena;Li, Huanxiu;Huang, Zhi;Tang, Yi;Zhang, Fen;Sun, Bo;Cheng, Wenjuan;Yao, Xingwei;Escalona, Victor Hugo;Qian, Guiping;Ma, Jie;Chen, Zhifeng
关键词：Mustard sprouts; Light quality; Melatonin; Growth; Nutritional quality
-
Individual and combined treatments of 2,4-epibrassinolide (EBR) and calcium chloride (CaCl2) maintain the postharvest quality of baby mustard
作者：Di, Hongmei;Liu, Ruobin;Zhang, Yutong;Huang, Huanhuan;Huang, Zhi;Tang, Yi;Li, Huanxiu;Sun, Bo;Zhang, Fen;Chen, Zhifeng;Ma, Jie;Escalona, Victor Hugo;Liu, Duchen
关键词：4-Epibrassinolide (EBR); Calcium chloride (CaCl 2 ); Baby mustard; Sensory; Pigment; Glucosinolate
-
Functional analysis of a lily SHORT VEGETATIVE PHASE ortholog in flowering transition and floral development
作者：Wu, Xiaomei;Ling, Wu;Pan, Yusha;Yang, Zhengmin;Yang, Yujie;Xiang, Wei;Chen, Jiren;Chen, Haixia;Li, Yufan;Zeng, Jianguo;Zhou, Li;Sun, Mengshan;Zheng, Sixiang;Ma, Jie;Ling, Wu
关键词：SHORT VEGETATIVE PHASE; Lilium x formolongi; Flower induction; Floral development
-
Systemic immune response of rainbow trout exposed to Flavobacterium psychrophilum infection
作者：Deng, Furong;Wang, Di;Yu, Yang;Lu, Tongyan;Li, Shaowu;Yu, Yang
关键词：Flavobacterium psychrophilum; Rainbow trout; Inflammatory response; Oxidative stress; Th1/Th2 responses; Tight junction
-
A Multi-Omics Analysis Revealed the Diversity of the MYB Transcription Factor Family's Evolution and Drought Resistance Pathways
作者：Zhang, Fan;Ma, Jie;Liu, Ying;Fang, Jing;Wei, Shuli;Xie, Rui;Han, Pingan;Zhao, Xiaoqing;Lu, Zhanyuan;Zhang, Fan;Ma, Jie;Liu, Ying;Fang, Jing;Wei, Shuli;Xie, Rui;Han, Pingan;Zhao, Xiaoqing;Lu, Zhanyuan;Zhang, Fan;Ma, Jie;Liu, Ying;Fang, Jing;Wei, Shuli;Xie, Rui;Han, Pingan;Zhao, Xiaoqing;Lu, Zhanyuan;Zhang, Fan;Ma, Jie;Liu, Ying;Fang, Jing;Wei, Shuli;Xie, Rui;Han, Pingan;Zhao, Xiaoqing;Lu, Zhanyuan;Ma, Jie;Liu, Ying;Fang, Jing;Wei, Shuli;Zhao, Xiaoqing;Lu, Zhanyuan;Ma, Jie;Liu, Ying;Fang, Jing;Wei, Shuli;Zhao, Xiaoqing;Lu, Zhanyuan;Bo, Suling
关键词：MYB transcription factor; drought; transcriptome; evolution; bioinformatics
-
A centromere map based on super pan-genome highlights the structure and function of rice centromeres
作者：Lv, Yang;Wang, Yueying;Jahan, Noushin;Ma, Jie;Qian, Qian;Guo, Longbiao;Lv, Yang;Liu, Congcong;Li, Xiaoxia;He, Huiying;He, Wenchuang;Chen, Wu;Yang, Longbo;Dai, Xiaofan;Cao, Xinglan;Yu, Xiaoman;Liu, Jiajia;Zhang, Bin;Wei, Hua;Zhang, Hong;Qian, Hongge;Shi, Chuanlin;Leng, Yue;Liu, Xiangpei;Guo, Mingliang;Wang, Xianmeng;Zhang, Zhipeng;Wang, Tianyi;Zhang, Bintao;Xu, Qiang;Cui, Yan;Zhang, Qianqian;Yuan, Qiaoling;Zhou, Yongfeng;Qian, Qian;Shang, Lianguang;Zheng, Xiaoming;Qian, Qian;Shang, Lianguang;Zheng, Xiaoming
关键词：centromere; super pan-genome; CentO satellite repeat; rice
