Uncovering key salt-tolerant regulators through a combined eQTL and GWAS analysis using the super pan-genome in rice

文献类型： 外文期刊

第一作者： Wei, Hua

作者： Wei, Hua;Wang, Xianmeng;Zhang, Zhipeng;Yang, Longbo;Zhang, Qianqian;Li, Yilin;He, Huiying;Chen, Dandan;Zhang, Bin;Leng, Yue;Cao, Xinglan;Cui, Yan;Shi, Chuanlin;Liu, Yifan;Lv, Yang;Ma, Jie;He, Wenchuang;Liu, Xiangpei;Xu, Qiang;Yuan, Qiaoling;Yu, Xiaoman;Wang, Tianyi;Qian, Hongge;Li, Xiaoxia;Zhang, Bintao;Zhang, Hong;Chen, Wu;Guo, Mingliang;Dai, Xiaofan;Qian, Qian;Shang, Lianguang;Zheng, Chongke;Xie, Xianzhi;Lv, Yang;Ma, Jie;Wang, Yuexing;Guo, Longbiao;Qian, Qian;Zheng, Xiaoming;Qian, Qian;Shang, Lianguang

作者机构：

关键词： super pan-genome; expression quantitative trait loci; GWAS; salt tolerance; rice

期刊名称：NATIONAL SCIENCE REVIEW （ 影响因子：20.6； 五年影响因子：22.3 ）

ISSN： 2095-5138

年卷期： 2024 年 11 卷 4 期

页码：

收录情况： SCI

摘要： For sessile plants, gene expression plays a pivotal role in responding to salinity stress by activating or suppressing specific genes. However, our knowledge of genetic variations governing gene expression in response to salt stress remains limited in natural germplasm. Through transcriptome analysis of the Global Mini-Core Rice Collection consisting of a panel of 202 accessions, we identified 22 345 and 27 610 expression quantitative trait loci associated with the expression of 7787 and 9361 eGenes under normal and salt-stress conditions, respectively, leveraging the super pan-genome map. Notably, combined with genome-wide association studies, we swiftly pinpointed the potential candidate gene STG5-a major salt-tolerant locus known as qSTS5. Intriguingly, STG5 is required for maintaining Na+/K+ homeostasis by directly regulating the transcription of multiple members of the OsHKT gene family. Our study sheds light on how genetic variants influence the dynamic changes in gene expression responding to salinity stress and provides a valuable resource for the mining of salt-tolerant genes in the future.

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