Inhibition of chitin deacetylases to attenuate plant fungal diseases

文献类型： 外文期刊

第一作者： Liu, Lin

作者： Liu, Lin;Yang, Qing;Liu, Lin;Yang, Qing;Liu, Lin;Li, Yingchen;Yan, Xiaojing;Liu, Wende;Yang, Qing;Xia, Yeqiang;Wang, Yan;Wang, Yuanchao;Xia, Yeqiang;Wang, Yan;Wang, Yuanchao;Xia, Yeqiang;Wang, Yan;Wang, Yuanchao;Zhou, Yong;Su, Xiaofeng;Cheng, Hongmei

作者机构：

期刊名称：NATURE COMMUNICATIONS （ 影响因子：16.6； 五年影响因子：17.0 ）

ISSN：

年卷期： 2023 年 14 卷 1 期

页码：

收录情况： SCI

摘要： Phytopathogenic fungi secrete chitin deacetylase (CDA) to escape the host's immunological defense during infection. Here, the authors reveal the common structural features of phytopathogenic fungal CDAs, and identify CDA inhibitors that are promising to control plant diseases. Phytopathogenic fungi secrete chitin deacetylase (CDA) to escape the host's immunological defense during infection. Here, we showed that the deacetylation activity of CDA toward chitin is essential for fungal virulence. Five crystal structures of two representative and phylogenetically distant phytopathogenic fungal CDAs, VdPDA1 from Verticillium dahliae and Pst_13661 from Puccinia striiformis f. sp. tritici, were obtained in ligand-free and inhibitor-bound forms. These structures suggested that both CDAs have an identical substrate-binding pocket and an Asp-His-His triad for coordinating a transition metal ion. Based on the structural identities, four compounds with a benzohydroxamic acid (BHA) moiety were obtained as phytopathogenic fungal CDA inhibitors. BHA exhibited high effectiveness in attenuating fungal diseases in wheat, soybean, and cotton. Our findings revealed that phytopathogenic fungal CDAs share common structural features, and provided BHA as a lead compound for the design of CDA inhibitors aimed at attenuating crop fungal diseases.

分类号：

  • 相关文献
作者其他论文 更多>>

微信小程序