Neuroprotective and antidiabetic lanostane-type triterpenoids from the fruiting bodies of Ganoderma theaecolum
文献类型： 外文期刊
第一作者： Guo, Jiaocen
作者： Guo, Jiaocen;Yan, Jiaoyang;Wu, Yougen;Guo, Jiaocen;Yang, Li;Dai, Luting;Ma, Qingyun;Xie, Qingyi;Dai, Haofu;Zhao, Youxing;Guo, Jiaocen;Yang, Li;Dai, Luting;Ma, Qingyun;Xie, Qingyi;Wu, Yougen;Dai, Haofu;Zhao, Youxing
作者机构：
关键词： Ganoderma theaecolum; Lanostane nortriterpenoids; Neuroprotective effects; PTP1B; alpha-Glucosidase
期刊名称：CHINESE JOURNAL OF NATURAL MEDICINES （ 影响因子：4.9； 五年影响因子：4.8 ）
ISSN： 2095-6975
年卷期： 2025 年 23 卷 2 期
页码：
收录情况： SCI
摘要：
Eight previously undescribed lanostane triterpenoids, including five nortriterpenoids with 26 carbons, ganothenoids A-E (1-5), and three lanostanoids, ganothenoids F-H (6-8), along with 24 known ones (9-32), were isolated from the fruiting bodies of Ganodrma theaecolum. The structures of the novel compounds were elucidated using comprehensive spectroscopic methods, including electronic circular dichroism (ECD) and nuclear magnetic resonance (NMR) calculations. Compounds 1-32 were assessed for their neuroprotective effects against H2O2-induced damage in human neuroblastoma SH-SY5Y cells, as well as their inhibitory activities against protein tyrosine phosphatase 1B (PTP1B) and alpha-glucosidase. Compound 4 demonstrated the most potent neuroprotective activity against H2O2-induced oxidative stress by suppressing G0/G1 phase cell cycle arrest, reducing reactive oxygen species (ROS) levels, and inhibiting cell apoptosis through modulation of B-cell lymphoma 2 protein (Bcl-2) and Bcl2 associated X-protein (Bax) protein expression. Compounds 26, 12, and 28 exhibited PTP1B inhibitory activities with IC50 values ranging from 13.92 to 56.94 mu mol
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