Chemical structure and antioxidant activity of a neutral polysaccharide from Asteris Radix et Rhizoma

文献类型： 外文期刊

第一作者： Zhu, Zuoyi

作者： Zhu, Zuoyi;Jiang, Yunzhu;Yao, Jiarong;Jiang, Yao;Li, Zhen;Dai, Fen;Song, Xinyue

作者机构：

关键词： Asteris Radix et Rhizoma; Polysaccharide; Structure; Antioxidant activity

期刊名称：CARBOHYDRATE POLYMERS （ 影响因子：10.723； 五年影响因子：9.964 ）

ISSN： 0144-8617

年卷期： 2022 年 286 卷

页码：

收录情况： SCI

摘要： Asteris Radix et Rhizoma (AR) has been widely used as a herbal medicine for treating various symptoms and possesses a number of bioactivities. A neutral polysaccharide ARP-1 was isolated from AR with weight-average molecular weight of 214 kDa. The heteropolysaccharide ARP-1 was composed of fucose, arabinose, galactose, glucose and mannose with a molar ratio of 0.40:14.25:10.22:1.06:0.41. Linkage and NMR analysis showed that ARP-1 had a backbone containing -> 3,6)-beta-D-Galp-(1 -> and -> 6)-beta-D-Galp-(1 -> residues, and oligosaccharide side chains containing Araf and Galp units were attached to the backbone at C-3 of -> 3,6)-beta-D-Galp-(1 -> residues. Antioxidant activity assays showed that ARP-1 exhibited potent antioxidant activities, including ABTS, hydroxy and DPPH radicals scavenging and reducing power. Besides, ARP-1 decreased the production of ROS and MDA, and improved the activities of SOD, which resulted in the protection of PC12 cells against H2O2-induced oxidative stress. The findings indicated that ARP-1 might be used as a potential natural antioxidant.

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