Interbatch quality control of the extract from Artemisia frigida Willd. by spectrum-effect relationship between HPLC fingerprints and the total antioxidant capacity

文献类型： 外文期刊

第一作者： Tian, Wei

作者： Tian, Wei;Dou, Jiahong;Li, Zhongyuan;Tian, Wei;Dou, Jiahong;Li, Zhongyuan;Yang, Juan;Li, Xiumei;Dai, Xiaofeng;Wang, Xiumin;Sun, Yahong

作者机构：

关键词： Artemisia frigida Willd; Extract; High performance liquid chromatography; Total antioxidant capacity; Spectrum-effect relationship

期刊名称：INTERNATIONAL JOURNAL OF FOOD PROPERTIES （ 影响因子：3.388； 五年影响因子：3.694 ）

ISSN： 1094-2912

年卷期： 2022 年 25 卷 1 期

页码：

收录情况： SCI

摘要： Similarity analysis of complicated chromatographic profiles is a potential protocol for the authentication and quality control of traditional Chinese medicine to guarantee prospective biological activity. In this work, a high-performance liquid chromatography (HPLC) method was established to identify and control the inter-assay quality of extract from Artemisia frigida Willd. Meanwhile, a partial least squares regression (PLSR) was applied to construct a spectrum-effect relationship between the HPLC fingerprints and the total antioxidant capacity of the extract from Artemisia frigida Willd. The similarity correlation coefficient of 10 batches of extract was >= 0.948 could guarantee the 10 batches of showed the inter-assay stability of antioxidant capacity of extract from Artemisia frigida Willd. Moreover, PLSR analysis showed that four efficacy-related components were closely related to antioxidant effect. Therefore, this study provided a flexible and efficient method for the quality and the stable biological activity assessment of Artemisia frigida Willd.

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