Aggregation-induced emission of TTCPy-3: A novel approach for eradicating Nocardia seriolae infections in aquatic fishes
文献类型： 外文期刊
第一作者： Liu, Zhigang
作者： Liu, Zhigang;Ma, Xiaona;Wang, Miao;Jiang, Lijin;Zhang, Meiyan;Lu, Maixin;Chang, Ouqin;Cao, Jianmeng;Ke, Xiaoli;Yi, Mengmeng;Liu, Zhigang;Zhang, Junling;Ma, Xiaona;Lu, Maixin;Cao, Jianmeng;Ke, Xiaoli
作者机构：
关键词： Aggregation-induced emission; TTCPy-3; Nocardia seriolae; Antibacterial activity; Zebrafish
期刊名称：BIOSENSORS & BIOELECTRONICS （ 影响因子：12.6； 五年影响因子：10.8 ）
ISSN： 0956-5663
年卷期： 2024 年 254 卷
页码：
收录情况： SCI
摘要： Aquatic fishes are threatened by the strong pathogenic bacterium Nocardia seriolae, which challenges the current prevention and treatment approaches. This study introduces luminogens with aggregation -induced emission (AIE) as an innovative and non -antibiotic therapy for N. seriolae. Specifically, the AIE photosensitizer, TTCPy-3 is employed against N. seriolae. We evaluated the antibacterial activity of TTCPy-3 and investigated the killing mechanism against N. seriolae, emphasizing its ability to aggregate within the bacterium and produce reactive oxygen species (ROS). TTCPy-3 could effectively aggregate in N. seriolae, generate ROS, and perform real-time imaging of the bacteria. A bactericidal efficiency of 100% was observed while concentrations exceeding 4 mu M in the presence of white light irradiation for 10 min. In vivo, evaluation on zebrafish (Danio rerio) confirmed the superior therapeutic efficacy induced by TTCPy-3 to fight against N. seriolae infections. TTCPy-3 offers a promising strategy for treating nocardiosis of fish, paving the way for alternative treatments beyond traditional antibiotics and potentially addressing antibiotic resistance.
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