文献类型： 外文期刊
第一作者： Han, Hui
作者： Han, Hui;Zhang, Shunfen;Zhong, Ruqing;Tang, Chaohua;Zhang, Junmin;Zhang, Hongfu;Yin, Jie
作者机构：
关键词： chlortetracycline; growth performance; gut microbiota; intestinal morphology; weaned piglets
期刊名称：JOURNAL OF APPLIED MICROBIOLOGY （ 影响因子：3.772； 五年影响因子：3.963 ）
ISSN： 1364-5072
年卷期：
页码：
收录情况： SCI
摘要： Aim Weaning stress can cause serious damage to piglet's health. Chlortetracycline (CTC) is widely used to ameliorate weaning stress and prevent infectious diseases in weaned piglets. However, antibiotics as growth promoters have to be limited because of increased antimicrobial resistance. In this study, we evaluated the effects of CTC on growth performance and intestinal functions in order to provide evidence for seeking antibiotic substitutes in weaned piglets. Methods and results A total of 20 weaned piglets were fed a basal diet or a diet supplemented with 75 mg/kg CTC. CTC decreased the crypt depth and increased the ratio of villus height to crypt depth, whilst failing to affect growth performance and serum biochemical parameters and cytokines. 16S rRNA sequencing suggested that CTC supplementation had no effect on the diversity and composition of colonic microbiota. Conclusion We speculated that gut microbiota is no longer sensitive to a low concentration of CTC due to the long-term use and low bioavailability of CTC in weaned piglets.
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