A new triterpenoid saponin from Gleditsia sinensis and its antiproliferative activity

文献类型： 外文期刊

第一作者： Liu, Chao

作者： Liu, Chao;Wang, Wei-Ting;Cheng, An-Wei;Guo, Xu;Sun, Jin-Yue;Liu, Chao;Wang, Wei-Ting;Cheng, An-Wei;Guo, Xu;Sun, Jin-Yue;Sun, Hui;Zhang, Jin-Bao

作者机构：

关键词： Gleditsia sinensis; triterpenoid saponin; antiproliferative

期刊名称：NATURAL PRODUCT RESEARCH （ 影响因子：2.861； 五年影响因子：2.572 ）

ISSN： 1478-6419

年卷期： 2016 年 30 卷 18 期

页码：

收录情况： SCI

摘要： Chemical investigation of the anomalous fruits of Gleditsia sinensis led to the isolation and identification of a new triterpenoid saponin, 3-O-beta-D-xylopyranosyl-(1 -> 2)-alpha-L-arabinopyranosyl-(1 -> 6)-beta-D-glucopyranosyl oleanolic acid 28-O-beta-D-xylopyranosyl-(1 -> 4)-alpha-L-rhamnopyrano--syl-(1 -> 4)-beta-D-xylopyranosyl-(1 -> 4)-alpha-L-rhamnopyranosyl-(1 -> 3)-beta-D-glucopyranosyl ester (1), along with other nine known compounds (2-10). All the isolates from this species were reported for the first time. The structure of Compound 1 was determined by a detailed analysis using various analytical techniques, including 1D and 2D NMR. In vitro antiproliferative activities of Compound 1 on MCF-7 and Hep-G2 tumor cell lines were evaluated. IC50 values against the two cell lines were 9.5 and 11.6M, respectively. [GRAPHICS] .

分类号： R9

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