The antibacterial and hemostatic curdlan hydrogel-loading epigallocatechin gallate for facilitating the infected wound healing

文献类型： 外文期刊

第一作者： Ding, Qiang

作者： Ding, Qiang;Wang, Xinyue;Chen, Meiling;Zhou, Fan;Liu, Zhengquan;Long, Ying;Zhao, Pingsen;Ding, Qiang;Wang, Xinyue;Chen, Meiling;Zhou, Fan;Liu, Zhengquan;Long, Ying;Xia, Xianzhu;Zhao, Pingsen;Ding, Qiang;Wang, Xinyue;Chen, Meiling;Zhou, Fan;Liu, Zhengquan;Long, Ying;Zhao, Pingsen;Ding, Qiang;Wang, Xinyue;Chen, Meiling;Zhou, Fan;Liu, Zhengquan;Long, Ying;Zhao, Pingsen;Ding, Qiang;Wang, Xinyue;Chen, Meiling;Zhou, Fan;Liu, Zhengquan;Long, Ying;Zhao, Pingsen;Mo, Zhendong;Xia, Xianzhu;Zhao, Pingsen

作者机构：

关键词： Curdlan; Epigallocatechin gallate; Antibacterial; Infected wound healing

期刊名称：INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES （ 影响因子：8.2； 五年影响因子：7.8 ）

ISSN： 0141-8130

年卷期： 2024 年 266 卷

页码：

收录情况： SCI

摘要： The infected wounds pose one of the major threats to human health today. To address this issue, it is necessary to develop innovative wound dressings with superior antibacterial activity and other properties. Due to its potent antibacterial, antioxidant, and immune-boosting properties, epigallocatechin gallate (EGCG) has been widely utilized. In this study, a multifunctional curdlan hydrogel loading EGCG (Cur-EGCGH3) was designed. CurEGCGH3 exhibited excellent physicochemical properties, good biocompatibility, hemostatic, antibacterial, and antioxidant activities. Also, ELISA data showed that Cur-EGCGH3 stimulated macrophages to secrete proinflammatory and pro-regenerative cytokines. Cell scratch results indicated that Cur-EGCGH3 promoted the migration of NIH3T3 and HUVECs. In vivo experiments confirmed that Cur-EGCGH3 could inhibit bacterial infection of the infected wounds, accelerate hemostasis, and promote epithelial regeneration and collagen deposition. These results demonstrated that Cur-EGCGH3 holds promise for promoting healing of the infected wounds.

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