文献类型： 外文期刊
第一作者： Dai, Luting
作者： Dai, Luting;Yu, Zhifang;Dai, Luting;Xie, Qingyi;Guo, Jiaocen;Ma, Qingyun;Yang, Li;Yuan, Jingzhe;Dai, Haofu;Zhao, Youxing;Dai, Luting;Xie, Qingyi;Guo, Jiaocen;Ma, Qingyun;Yang, Li;Yuan, Jingzhe;Dai, Haofu;Zhao, Youxing
作者机构：
关键词： Cladosporium sp.; marine-derived fungus; neuroprotective effects; protein tyrosine phosphatase 1B (PTP1B); antifungal activity
期刊名称：JOURNAL OF OCEANOLOGY AND LIMNOLOGY （ 影响因子：1.6； 五年影响因子：1.6 ）
ISSN： 2096-5508
年卷期： 2024 年
页码：
收录情况： SCI
摘要： A new isochromanone, cladosporinisochromanone (1), accompanied by 15 known compounds (2-16) were obtained from secondary metabolites produced by marine-derived fungus Cladosporium sp. DLT-5. NMR and HRESIMS spectra elucidation determined the planar structure of 1. Subsequent electronic circular dichroism (ECD) experiment assigned the absolute configuration of 1. Compounds 1, 2, 4-6, and 10 displayed different degrees of neuroprotective activities on human neuroblastoma cells SH-SY5Y. Five compounds (1, 3-5, and 13) emerged resistance to protein tyrosine phosphatase 1B (PTP1B), further kinetic analysis and molecular docking study indicated that the most potent compound 13 (IC50 value of 10.74 +/- 0.61 mu mol/L) was found as a noncompetitive inhibitor for PTP1B. Surface plasmon resonance (SPR) and molecular docking studies also demonstrated the interaction between compound 12 and Niemann-Pick C1 Like 1 (NPC1L1), which has been identified as significant therapeutic target for hypercholesteremia. In addition, compounds 3, 6, and 14 showed attractive inhibitory activity against the phytopathogenic fungi: Colletotrichum capsici. Therefore, library of Cladosporium metabolites is enriched and new active uses of known compounds are explored.
分类号：
- 相关文献
作者其他论文 更多>>
-
Bacterial cellulose and photothermal material from biomass-based zero-waste biorefinery functionalized chitosan film for sustainable active food packaging
作者：Yang, Li;Sheng, Wenyang;Yang, Yichen;He, Kaiwen;Jiang, Guangyang;Tian, Yongqiang;Yang, Li;Sheng, Wenyang;Yang, Yichen;He, Kaiwen;Jiang, Guangyang;Tian, Yongqiang;Yang, Ying
关键词：Zero-waste biorefining; Bacterial cellulose; Photothermal material; Chitosan; Antibacterial activity; Distillers' grains
-
New Isocoumarins from an Endophytic Fungal Strain Diaporthe arengae M2 and their Antibacterial Activities
作者：Liu, De-Sui;Ma, Qing-Yun;Yang, Li;Xie, Qing-Yi;Dai, Hao-Fu;Zhao, You-Xing;Liu, De-Sui;Ma, Qing-Yun;Yang, Li;Xie, Qing-Yi;Dai, Hao-Fu;Zhao, You-Xing;Liu, De-Sui;Zhang, Jun-Feng;Wu, You-Gen
关键词：Endophytic fungi;
Diaporthe sp.; Isocoumarin derivatives; Antibacterial activity -
Syntaxin 17 Translocation Mediated Mitophagy Switching Drives Hyperglycemia-Induced Vascular Injury
作者：Luo, Anqi;Liu, Xiaoquan;Liu, Haochen;Wang, Rui;Zheng, Yunsi;Gong, Jingwen;Wang, Shuting;Yun, Chuan;Chen, Zongcun;Jiang, Yanan;Dai, Haofu
关键词：(diabetes; Fis1; mitophagy; Syntaxin 17); vascular endothelial injury
-
Identification of targets and comparative study of administration methods for the lipid-lowering effects of fucoidan from Saccharina japonica
作者：Chen, Pengwei;Wang, Hao;Chen, Huiqin;Dai, Haofu;Hao, Li;Li, Quancai;Zhang, Miao;Jiang, Hongfei;Zhang, Renshuai;Jia, Ang
关键词：Fucoidan; Lipid-lowering activity; Dietary supplementation; Intestinal target; Gut microbiota
-
Temperature-controllable antibacterial film mediated by a photoresponsive metal-polyphenol framework for long-term food preservation
作者：Jiang, Guangyang;Sheng, Wenyang;Yang, Li;Yang, Yichen;Tian, Yongqiang;Jiang, Guangyang;Sheng, Wenyang;Yang, Li;Yang, Yichen;Tian, Yongqiang;Tang, Tingting;Wang, Chenzhi
关键词：Cu-CGA nanoparticles; Photothermal; Antimicrobial activity; Food packaging; Cherry tomatoes preservation
-
Comprehensive Analysis of Hormonal Signaling Pathways and Gene Expression in Flesh Segment Development of Chinese Bayberry (Myrica rubra)
作者：Fu, Yihan;Yang, Li;Zong, Yu;Li, Yongqiang;Chen, Wenrong;Liao, Fanglei;Guo, Weidong;Zhang, Shuwen;Qi, Xingjiang;Yang, Li;Zong, Yu;Li, Yongqiang;Chen, Wenrong;Liao, Fanglei;Guo, Weidong
关键词：Chinese bayberry; flesh segments; fruit development; endogenous hormones; transcriptome analysis; paraffin sectioning; immunofluorescence localization
-
EasyMetagenome: A user-friendly and flexible pipeline for shotgun metagenomic analysis in microbiome research
作者：Bai, Defeng;Xun, Jiani;Ma, Chuang;Luo, Hao;Yang, Haifei;Hou, Huiyu;Lv, Hujie;Wan, Xiulin;Wang, Yao;Yousuf, Salsabeel;Zeng, Meiyin;Zhang, Tianyuan;Gao, Yunyun;Liu, Yong-Xin;Chen, Tong;Ma, Chuang;Yang, Haifei;Cao, Chen;Cao, Xiaofeng;Cui, Jianzhou;Deng, Yuan-Ping;Deng, Zhaochao;Yu, Hao;Zhang, Chunfang;Dong, Wenxin;Dong, Wenxue;Du, Juan;Fang, Qunkai;Fang, Wei;Fang, Yue;Luan, Yaning;Fu, Fangtian;Fu, Min;Fu, Yi-Tian;Gao, He;Ge, Jingping;Guo, Yuhao;Gong, Qinglong;Lou, Wenbo;Gu, Lunda;Yang, Li;Guo, Peng;Hai, Tang;Liu, Hao;He, Jieqiang;He, Zi-Yang;Huang, Can;Ji, Shuai;Jiang, ChangHai;Jiang, Gui-Lai;Jiang, Lingjuan;Jin, Ling N.;Li, Changchao;Kan, Yuhe;Kang, Da;Kou, Jin;Lam, Ka-Lung;Li, Chong;Li, Fuyi;Li, Liwei;Li, Miao;Li, Xin;Li, Ye;Li, Zheng-Tao;Zhu, Chengshuai;Liang, Jing;Mo, Jiayuan;Lin, Yongxin;Liu, Changzhen;Liu, Danni;Zhang, Jing;Chen, Shifu;Liu, Fengqin;Liu, Jia;Liu, Tianrui;Liu, Tingting;Wang, Xinlong;Liu, Xinyuan;Luo, Yuanyuan;Liu, Yaqun;Liu, Bangyan;Liu, Minghao;Lv, Hujie;Ma, Tengfei;Mai, Zongjiong;Niu, Dongze;Pan, Zhuo;Qi, Heyuan;Shi, Zhanyao;Song, Chunjiao;Sun, Fuxiang;Sun, Yan;Tian, Sihui;Wang, Guoliang;Wang, Hongyang;Wang, Hongyu;Wang, Huanhuan;Wang, Jing;Wang, Jun;Wang, Kang;Wang, Leli;Yao, Xiaofang;Wang, Shao-kun;Xiao, Zufei;Xing, Huichun;Xu, Yifan;Yang, Song;Yan, Shu-yan;Zhang, Yi-Bo;Yang, Yuanming;Lei, Yu;Yuan, Zhengrong;Zhang, Chunge;Zhang, Huimin;Zhang, Na;Zhang, Yupeng;Zhang, Zheng;Zhou, Mingda;Zhou, Yuanping;Zhu, Zhihao;Zhu, Lin;Zhu, Yue;Zou, Hongqin;Zuo, Anna;Dong, Wenxuan;Wen, Tao;Chen, Shifu;Chen, Shifu;Li, Guoliang
关键词：metagenome; microbiome; microbiota; pipeline; visualization
