Decreased Cdk2 Activity Hindered Embryonic Development and Parthenogenesis Induction in Silkworm, Bombyx mori L.

文献类型： 外文期刊

第一作者： Hu, Chengjie

作者： Hu, Chengjie;Jiang, Yonghou;Ma, Chenkai;Xu, Fang;Yu, Wei;Xu, Xia;Hu, Chengjie;Ma, Chenkai;Xu, Fang;Cui, Chunguang;Du, Xin;Chen, Jine;Zhu, Linbao;Yu, Shaofang;He, Xingjian;Wang, Yongqiang;Xu, Xia

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关键词： Cdk2; AUZ454; oocytes; embryo; silkworm

期刊名称：INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES （ 影响因子：4.9； 五年影响因子：5.7 ）

ISSN： 1661-6596

年卷期： 2025 年 26 卷 7 期

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收录情况： SCI

摘要： Cyclin-dependent protein kinase 2 (Cdk2), an important member of the serine/threonine-specific protein kinase family, plays a critical regulatory role in biological processes. Previous studies have demonstrated that Cdk2 is involved in the arrest and resumption of meiosis in mammalian oocytes. In this study, we explored the function of Cdk2 through parthenogenetic lines (PLs) and corresponding amphigonic lines (ALs) in a model lepidopteran insect silkworm, Bombyx mori L. Our findings revealed a positive correlation between Cdk2 activity and the parthenogenesis induction rate. The pharmacological inhibition of Cdk2 using the specific inhibitor AUZ454 not only significantly reduced the parthenogenesis induction rate but also caused developmental delays in embryos. These results demonstrate that Cdk2 is essential for parthenogenesis success and is a potential target gene for biological reproductive regulation.

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