Secondary metabolites from Penicillium sp. HS-11, a fungal endophyte of Huperzia serrata

文献类型： 外文期刊

第一作者： Ying, Youmin

作者： Ying, Youmin;Lei, Panyi;Xu, Yilian;Lin, Yuhao;Yang, Nini;Han, Yiwei;Shan, Weiguang;Wang, Jianwei;Xu, Yilian;Rao, Guiwei;Zhang, Zhidong

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关键词： Fungal endophyte; Penicillium; Huperzia serrata; Sorbicillinoid; beta-Glucuronidase

期刊名称：FITOTERAPIA （ 影响因子：3.4； 五年影响因子：3.3 ）

ISSN： 0367-326X

年卷期： 2024 年 175 卷

页码：

收录情况： SCI

摘要： Three new sorbicillinoids sorbicatechols E-G (1-3), along with seven known compounds 4-10, were obtained from the ethanol extract of Penicillium sp. HS-11, a fungal endophyte of the medicinal plant Huperzia serrata. The structures of 1-3 were established by detailed interpretation of the spectroscopic data and their absolute configurations were established by comparative analyses of the ECD spectra. Sorbicatechol G (3) represented the first hybrid sorbicillinoid bearing a tetralone skeleton. In the in-vitro bioassay, trichodimerol (5) exhibited moderate inhibitory activity against the Escherichia coli beta-glucuronidase (EcGUS) with an IC50 value of 92.0 +/- 9.4 mu M.

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