20(S)-Protopanaxadiol saponins inhibit SKOV3 cell migration

文献类型: 外文期刊

第一作者: Li, Bin

作者: Li, Bin;Chen, Daomei;Li, Wanyi;Xiao, Dan

作者机构:

关键词: Panax notoginseng saponins;migration;ostopontin;ovarian cancer;SKOV3 cells;tube formation

期刊名称:ONCOLOGY LETTERS ( 影响因子:2.967; 五年影响因子:2.575 )

ISSN: 1792-1074

年卷期: 2016 年 11 卷 3 期

页码:

收录情况: SCI

摘要: While the anti-tumor actions of ginsenosides from Panax notoginseng are well-studied, the anti-proliferative activity of 20(S)-protopanaxadiol saponins (PDS) in Sanchi ginseng on human ovarian cancer has not been reported, nor has its effect on migration of SKOV3 cells been investigated. In the present study, a wound-healing assay indicated that PDS inhibited the migration of SKOV3 cells, and a Matrigel tube formation assay demonstrated the presence of inhibitory tube-structures following treatment with PDS. To date, there are no previous reports on the regulation of osteopontin (OPN), a glycophosphoprotein cytokine frequently expressed in ovarian carcinoma effusions by PDS. A reduction in the expression of OPN following PDS-treatment was observed using immunohistochemical and western blot experiments. These results suggest that PDS may be useful in the search for a potential ovarian cancer treatment.

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