Phenylhydrazone Alkaloids from the Deep-Sea Cold Seep Derived Fungus Talaromyces amestolkiae HDN21-0307

文献类型： 外文期刊

第一作者： Wu, Jiajin

作者： Wu, Jiajin;Wang, Wenxue;Yang, Yuhuan;Shah, Mudassir;Zhou, Luning;Zhang, Guojian;Che, Qian;Li, Jing;Zhu, Tianjiao;Li, Dehai;Peng, Jixing;Zhang, Guojian;Li, Dehai;Li, Jing;Zhu, Tianjiao;Li, Dehai

作者机构：

期刊名称：JOURNAL OF NATURAL PRODUCTS （ 影响因子：5.1； 五年影响因子：4.5 ）

ISSN： 0163-3864

年卷期： 2024 年 87 卷 5 期

页码：

收录情况： SCI

摘要： Alkaloids with a phenylhydrazone architecture are rarely found in nature. Four unusual phenylhydrazone alkaloids named talarohydrazones A-D (1-4) were isolated from the deep-sea cold seep derived fungus Talaromyces amestolkiae HDN21-0307 using the one strain-many compounds (OSMAC) approach and MS/MS-based molecular networking (MN) combined with network annotation propagation (NAP) and the unsupervised substructure annotation method MS2LDA. Their structures were elucidated by spectroscopic data analysis, single-crystal X-ray diffraction, and quantum chemical calculations. Talarohydrazone A (1) possessed an unusual skeleton combining 2,4-pyridinedione and phenylhydrazone. Talarohydrazone B (2) represents the first natural phenylhydrazone-bearing azadophilone. Bioactivity evaluation revealed that compound 1 exhibited cytotoxic activity against NCI-H446 cells with an IC50 value of 4.1 mu M. In addition, compound 1 displayed weak antibacterial activity toward Staphylococcus aureus with an MIC value of 32 mu g/mL.

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