Promotion and Inhibition of Ruminal Epithelium Growth by Butyric Acid and Insulin-Like Growth Factor-1 (IGF-1) in Dairy Goats

文献类型： 外文期刊

第一作者： Liu Da-cheng

作者： Liu Da-cheng;Zhou Xiang-li;Liu Guo-juan;Liu Da-cheng;Zhou Xiang-li;Liu Guo-juan;Gao Min;Hu Hong-lian

作者机构：

关键词： butyrate;IGF-1;rumen epithelium

期刊名称：JOURNAL OF INTEGRATIVE AGRICULTURE （ 影响因子：2.848； 五年影响因子：2.979 ）

ISSN： 2095-3119

年卷期： 2014 年 13 卷 9 期

页码：

收录情况： SCI

摘要： Isolated ruminal epithelia from caudal blind sacs of dairy goats were incubated with butyrate and insulin-like growth factor-1 (IGF-1) at different concentrations. Proportions of ruminal epithelium in different phases of the cell division cycle were determined by flow cytometric analysis. The proportion of epithelial cells in S phase and G(2)-M phase (PS&G2-M) increased significantly (P<0.01) whereas the proportion of epithelial cells in G(0)-G(1) phase (PG0-G1) decreased after incubation with IGF-1. PS&G2-M decreased whereas PG0-G1 increased markedly (P<0.01) after incubation with sodium butyrate. PS&G2-M, incubated with IGF-1 and butyrate sodium together increased more than that incubated with IGF-1 alone; PG0-G1, however, decreased significantly (P<0.01). Our results indicate that IGF-1 enhances whereas sodium butyrate inhibits the proliferation of rumen epithelial cells. Furthermore, butyrate and IGF-1, together, have a synergic effect on the proliferation of rumen epithelium.

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