A Galactose-Functionalized Pyrrolopyrrole Aza-BODIPY for Highly Efficient Detection of Eight Aliphatic and Aromatic Biogenic Amines: Monitoring Food Freshness and Bioimaging

文献类型： 外文期刊

第一作者： Gan, Yujing

作者： Gan, Yujing;Lu, Bingli;Zhong, Jintian;Cao, Derong;Wang, Lingyun;Ran, Xueguagn

作者机构：

关键词： aromatic biogenic amines; chromophore reaction; galactose; synthesis; noncovalent interactions; aliphatic biogenic amines

期刊名称：BIOSENSORS-BASEL （ 影响因子：5.6； 五年影响因子：5.7 ）

ISSN：

年卷期： 2025 年 15 卷 8 期

页码：

收录情况： SCI

摘要： The detection of aliphatic and aromatic biogenic amines (BAs) is important in food spoilage, environmental monitoring, and disease diagnosis and treatment. Existing fluorescent probes predominantly detect aliphatic BAs with single signal variation and low sensitivity, impairing the adaptability of discriminative sensing platforms. Herein, we present a visual chemosensor (galactose-functionalized pyrrolopyrrole aza-BODIPY, PPAB-Gal) that simultaneously detects eight aliphatic and aromatic BAs in a real-time and intuitive way based on their unique electronic and structural features. Our findings reveal that the dual colorimetric and ratiometric emission changes are rapidly produced in presence of eight BAs through a noncovalent interaction (pi-pi stacking and hydrogen bond)-assisted chromophore reaction. Specifically, other lone-pair electrons containing compounds, such as secondary amines, tertiary amines, NH3, and thiol, fail to exhibit these changes. As a result, superior sensing performances with distinctly dual signals (Delta lambda(ab) = 130 nm, Delta lambda(em) = 150 nm), a low LOD (similar to 25 nM), and fast response time (<2 min) were obtained. Based on these advantages, a qualitative and smartphone-assisted sensing platform with a PPAB-Gal-loaded TLC plate is developed for visual detection of putrescine and cadaverine vapor. More importantly, we construct a connection between a standard quantitative index for the TVBN value and fluorescence signals to quantitatively determine the freshness of tuna and shrimp, and the method is facile and convenient for real-time and on-site detection in practical application. Furthermore, since the overexpressed spermine is an important biomarker of cancer diagnosis and treatment, PPAB-Gal NPs can be used to ratiometrically image spermine in living cells. This work provides a promising sensing method for BAs with a novyel fluorescent material in food safety fields and biomedical assays.

分类号：

  • 相关文献
作者其他论文 更多>>

微信小程序