Viral Replication and Lung Lesions in BALB/c Mice Experimentally Inoculated with Avian Metapneumovirus Subgroup C Isolated from Chickens

文献类型： 外文期刊

第一作者： Wei, Li

作者： Wei, Li;Zhu, Shanshan;Wang, Jing;Yan, Xu;Zhang, Chunyan;Liu, Shuhang;Quan, Rong;Li, Zixuan;Liu, Jue;She, Ruiping;Hu, Fengjiao;Du, Fang;Wei, Ting

作者机构：

期刊名称：PLOS ONE （ 影响因子：3.24； 五年影响因子：3.788 ）

ISSN： 1932-6203

年卷期： 2014 年 9 卷 3 期

页码：

收录情况： SCI

摘要： Avian metapneumovirus (aMPV) emerged as an important respiratory pathogen causing acute respiratory tract infection in avian species. Here we used a chicken aMPV subgroup C (aMPV/C) isolate to inoculate experimentally BALB/c mice and found that the aMPV/C can efficiently replicate and persist in the lungs of mice for at least 21 days with a peak viral load at day 6 postinoculation. Lung pathological changes were characterized by increased inflammatory cells. Immunochemical assay showed the presence of viral antigens in the lungs and significant upregulation of pulmonary inflammatory cytokines and chemokines including MCP-1, MIP-1 alpha, RANTES, IL-1 beta, IFN-gamma, and TNF-alpha were detected following inoculation. These results indicate for the first time that chicken aMPV/C may replicate in the lung of mice. Whether aMPV/C has potential as zoonotic pathogen, further investigation will be required.

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