Integrative transcriptomic and metabolomic analysis in mice reveals the mechanism by which ginseng stem-leaf saponins enhance mucosal immunity induced by a porcine epidemic diarrhea virus vaccination

文献类型： 外文期刊

第一作者： Su, Fei

作者： Su, Fei;Ye, Shiyi;Yu, Bin;Li, Junxing;Xu, Lihua;Yuan, Xiufang;Xue, Yin

作者机构：

关键词： Ginseng stem-leaf saponins; Porcine epidemic diarrhea virus; Mucosal immunity; Transcriptomic analysis; Metabolomic profile

期刊名称：VACCINE （ 影响因子：5.5； 五年影响因子：4.3 ）

ISSN： 0264-410X

年卷期： 2023 年 41 卷 42 期

页码：

收录情况： SCI

摘要： Porcine epidemic diarrhea virus (PEDV) is a main cause of severe enteric disease in piglets, leading to millions of dollars lost annually in the global pig industry. Parenteral vaccination is limited in generating sufficient mucosal immunity, which is crucial for early defense against PEDV. Here, we orally administered ginseng stem-leaf sa-ponins (GSLS) to mice before parenteral vaccination and found that GSLS significantly enhanced the phagocy-tosis of dendritic cells, promoted the activities of CD4+ T cells and increased PEDV-specific IgA antibodies in the intestinal mucosa. Transcriptomic results showed that the altered genes following GSLS treatment were mostly related to the immune response and metabolism. In addition, integrated analysis of the transcriptome and metabolome revealed that the mechanism by which GSLS enhances mucosal immunity may be associated with progesterone-related pathways. Further studies are needed to explore the detailed molecular mechanisms.

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