Epirubicin-encapsulated long-circulating thermosensitive liposome improves pharmacokinetics and antitumor therapeutic efficacy in animals

文献类型： 外文期刊

第一作者： Wu, Yan

作者： Wu, Yan;Zhang, Fu-Cheng;Yang, Yuan;Wu, Cheng;Lue, Wan-Liang;Wu, Yan;Yang, Yuan;Wu, Cheng;Mei, Xing-Guo

作者机构：

关键词： Thermosensitive;liposome;pharmacokinetics;epirubicin hydrochloride;antitumor

期刊名称：JOURNAL OF LIPOSOME RESEARCH （ 影响因子：3.648； 五年影响因子：3.649 ）

ISSN： 0898-2104

年卷期： 2011 年 21 卷 3 期

页码：

收录情况： SCI

摘要： In the present work, a long-circulating epirubicin hydrochloride (EPI)-containing thermosensitive liposome aiming at antitumor therapy, DPPC/MSPC/DSPG/DSPE-mPEG(2000) (EPI-LTSL), was developed and evaluated. Nonthermosensitive and traditional liposomes, HSPC/cholesterol/DSPG/DSPE-mPEG(2000) (EPI-NTSL) and HSPC/cholesterol (EPI-LIP), were also prepared at the same time for comparison. Temperature-dependent EPI release from loaded liposomes in vitro was characterized by the fluorescence method. Different liposome preparations were administered in rats by intravenous injection at the same dosage of 12 mg.kg(-1). EPI and internal standard daunorubicin hydrochloride (DAU) were analyzed by high-performance liquid chromatography and verified by LC tandem mass spectrometry. In the pharmacodynamics study, the EPI-LTSL was combined with local hyperthermia for target-specific delivery to the anesthetized and tumor-bearing mice. According to the in vitro results, more than 90% of loaded EPI was released from MSPC-containing liposome (EPI-LTSL) within 4 minutes at 43 degrees C, while at 37 degrees C, less than 5% was released beyond 60 minutes. However, less than 5% of drug was released at 43 degrees C for the other two liposomes without MSPC (EPI-NTSL and EPI-LIP). The results of the pharmacokinetics study in rats showed that not only the circulation time of EPI was prolonged significantly, but also the concentration in vivo was promoted for EPI-LTSL, compared to EPI-NTSL and EPI-solution. The mean tumor inhibitory rate for EPI-LTSL, EPI-NTSL, and EPI-solution were 61.1, 39.6, and 43.1%, respectively.

分类号：

  • 相关文献

[1]Validated hydrophilic interaction LC-MS/MS method for simultaneous quantification of dacarbazine and 5-amino-4-imidazole-carboxamide in human plasma. Yang, Yuhui,Zhang, Weihua,Liu, Yanhong.

[2]Quantification of pegylated liposomal doxorubicin and doxorubicinol in rat plasma by liquid chromatography/electro spray tandem mass spectroscopy: Application to preclinical pharmacokinetic studies. Yang, Yuhui,Liu, Yanhong,Liu, Xiangtao,Jiang, Tao.

[3]Optimisation of preparation conditions and properties of phytosterol liposome-encapsulating nattokinase. Dong, Xu-Yan,Wang, Zhan,Zhao, Yuan-Di,Dong, Xu-Yan,Kong, Fan-Pi,Yuan, Gang-You,Wei, Fang,Jiang, Mu-Lan,Li, Guang-Ming,Chen, Hong.

[4]Optimization of the Transfection Efficiency of Buffalo Fetal Fibroblasts Cells Using Liposome. Deng, Tingxian,Pang, Chunying,Zhang, Yingyin,Yang, Bingzhuang,Liang, Xianwei. 2013

[5]Development of liposomal Ganoderma lucidum polysaccharide: Formulation optimization and evaluation of its immunological activity. Liu, Zhenguang,Huang, Yee,Bo, Ruonan,Gao, Zhenzhen,Yu, Yun,Hu, Yuanliang,Liu, Jiaguo,Wu, Yi,Wang, Deyun,Ma, Xia,Deng, Bihua.

[6]Antitumor Effects of Orally and Intraperitoneally Administered Chitosan Oligosaccharides (COSs) on Si 80-Bearing/Residual Mouse. Zou, Pan,Yang, Xin,Zhang, Yanxin,Wang, Jing,Zou, Pan,Yang, Xin,Zhang, Yanxin,Du, Pengfei,Wang, Jing,Du, Pengfei,Wang, Jing,Zou, Pan,Yuan, Shoujun,Yang, Dexuan. 2016

[7]Antitumor Peptides from Marine Organisms. Lin, Xiu-Kun,Lin, Xiu-Kun,Zheng, Lan-Hong,Wang, Yue-Jun,Sheng, Jun,Wang, Fang,Zheng, Yuan,Sun, Mi. 2011

[8]Antitumor activity of bee pollen polysaccharides from Rosa rugosa. Wang, Bo,Zhang, Zhongyu,Liu, Yang,Gao, Qipin,Zhou, Yifa,Li, Shanshan,Diao, Qiyu.

[9]Polysaccharides from Phellinus linteus inhibit cell growth and invasion and induce apoptosis in HepG2 human hepatocellular carcinoma cells. Wang, Guibin,Dong, Lulu,Zhang, Yuanyuan,Zhao, Min,Ji, Yuanyuan,Xiang, Wenhua.

[10]Advances in mushroom research in the last decade. Fan, Leifa,Pan, Huijuan,Soccol, Andrea Thomaz,Pandey, Ashok,Soccol, Carlos Ricardo. 2006

[11]Antitumor and immunomodulatory activity of arabinoxylans: A major constituent of wheat bran. Zhou, Sumei,Cao, Li,Liu, Xiuzhen,Qian, Tianxiu,Sun, Guibo,Guo, Yan,Chang, Fengjin,Sun, Xiaobo,Cao, Li,Liu, Xiuzhen,Qian, Tianxiu,Sun, Guibo,Guo, Yan,Chang, Fengjin,Sun, Xiaobo.

[12]Cytotoxic, Antitumor and Immunomodulatory Effects of the Water-Soluble Polysaccharides from Lotus (Nelumbo nucifera Gaertn.) Seeds. Zheng, Yafeng,Wang, Qi,Zhuang, Weijing,Lu, Xu,Zheng, Baodong,Wang, Qi,Miron, Anca,Chai, Tsun-Thai,Xiao, Jianbo.

[13]Syntheses and in vitro Antitumor Activities of N-Acetyl Pyrazolines and Diphenyl Etheryl N-Acetyl Bis-pyrazolines. Zhang Yingpeng,Tan Wei,Yang Yunshang,Sun Shiqi,Guo Huichen. 2015

[14]Identification and functional characterization of a novel fungal immunomodulatory protein from Postia placenta. Li, Shu Ying,Ding, Yang,Nie, Ying,Tang, Xuan Ming,Shi, Li Jun. 2015

[15]Antitumor Activity of DMAKO-05, a Novel Shikonin Derivative, and Its Metabolism in Rat Liver Microsome. Zhang, Xu,Wang, Ru-Bing,Zhou, Wen,Meng, Qing-Qing,Li, Shao-Shun,Xiao, Sui. 2015

[16]Recombinant Expression of a Novel Fungal Immunomodulatory Protein with Human Tumor Cell Antiproliferative Activity from Nectria haematococca. Li, Shuying,Nie, Ying,Ding, Yang,Tang, Xuanming,Shi, Lijun. 2014

[17]Synthesis and biological evaluation of novel 6-chloro-quinazolin derivatives as potential antitumor agents. Luo, Hui,Cai, Yongqiang,Peng, Zhijun,Liu, Tao,Yang, Shengjie,Luo, Hui,Yang, Shengjie. 2014

[18]Synthesis and Cytotoxicity Evaluation of 13-n-Alkyl Berberine and Palmatine Analogues as Anticancer Agents. Zhang, Lei,Li, Jingjing,Li, Naisan,Wang, Jing,Wang, Yongbin,Yao, Qizheng,Ma, Fei,Ma, Fei,Yao, Shining,Wang, Xiuzhen. 2012

[19]Cultivation and bioactivity assessment of Grifola frondosa fruiting bodies on olive oil press cakes substrates. Gregori, Andrej,Klinar, Dusan,Svagelj, Mirjan,Berovic, Marin,Liu, Yanfang,Zhang, Jingsong,Pohleven, Franc.

[20]Therapeutic efficacy of an hTERT promoter-driven oncolytic adenovirus that expresses apoptin in gastric carcinoma. Li, Xiao,Zhu, Guangze,Guan, Guofang,Liu, Lei,Li, Xiao,Chi, Baorong,Liu, Liming,Liu, Lei,Wu, Wenbin,Zhu, Guangze,Liu, Liming,Guan, Guofang,Li, Xiao,Jin, Ningyi. 2012

作者其他论文 更多>>

微信小程序