Efficient biotransformation for preparation of pharmaceutically active ginsenoside Compound K by Penicillium oxalicum sp 68

文献类型: 外文期刊

第一作者: Gao, Juan

作者: Gao, Juan;Liang, Fei;Jin, Rutian;Wu, Di;Tai, Guihua;Zhou, Yifa;Xu, Wenjing;Fang, Qiang

作者机构:

关键词: Ginsenoside;Compound K;Biotransformation;Penicillium oxalicum;Glycosidase

期刊名称:ANNALS OF MICROBIOLOGY ( 影响因子:2.112; 五年影响因子:2.151 )

ISSN: 1590-4261

年卷期: 2013 年 63 卷 1 期

页码:

收录情况: SCI

摘要: Pathogenic fungus Penicillium oxalicum sp. 68 was screened from soil and identified by ITS sequencing. The strain was found to be able to transform protopanaxadiol-type ginsenosides to produce a series of bioactive metabolites. Glycosidase from the culture of P. oxalicum sp. 68 was partially purified with a simple two-step procedure consisting of DEAE-cellulose chromatography and ammonium sulfate precipitation. Bioactive ginsenoside Compound K was prepared selectively and efficiently by biotransformation of ginsenosides Rb1, Rb2, Rc and Rd using the partially purified glycosidase. The optimal conditions for transforming Rb1 into Compound K were pH 4.0, 55 A degrees C and 0.5 mg mL(-1) Rb1. The sole product is Compound K and the maximum yield reached 87.7 % (molar ratio). The transformation pathways of Rb1, Rb2, Rc and Rd are Rb1 -> Rd -> F2 -> Compound K, Rb2 -> CO -> CY -> Compound K, Rc -> Mb -> Mc -> Compound K and Rd -> F2 -> Compound K, respectively. This biotransformation method showed great potential for preparing minor bioactive ginsenosides, especially Compound K, in the pharmaceutical industry because of its high specificity and favorable environmental compatibility.

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