SYNTHESIS AND STRUCTURE-ANTITUMOR ACTIVITY RELATIONSHIP OF SULFONYL 5-FLUOROURACIL DERIVATIVES
文献类型: 外文期刊
第一作者: Chen, Fan
作者: Chen, Fan;Zhao, Kejian;Hu, Maolin;Hou, Yong
作者机构:
关键词: Anticancer activities;crystal structure;sulfonyl 5-fluorouracil derivatives
期刊名称:PHOSPHORUS SULFUR AND SILICON AND THE RELATED ELEMENTS ( 影响因子:1.082; 五年影响因子:0.859 )
ISSN: 1042-6507
年卷期: 2010 年 185 卷 1 期
页码:
收录情况: SCI
摘要: Novel sulfonyl 5-fluorouracil derivatives 2 (5-fluoro-1-(arylsulfonyl) pyrimidine-2,4(1H,3H)-diones) have been synthesized via the reaction of 5-fluorouracil with sulfonyl chloride. Their chemical structures were confirmed by means of (1)HNMR, (13)C NMR, IR, mass spectra, and elemental analyses, and, in the case of 2a, its structure was established by single crystal X-ray diffraction. Some of the compounds were assayed for anticancer (HL-60 and BEL-7402 cells) activities. Structure-activity relationship (SAR) analysis discovered that the anticancer activity was related to the configuration, and that electron-withdrawing groups at 2-position or 4-position on the aryl group of arylsulfonyl derivatives of 5-fluorouracil could enhance the anticancer activity against the BEL-7402 cells.
分类号:
- 相关文献
作者其他论文 更多>>
-
3-methyl-4-nitrophenol disturbs the maternal-to-zygotic transition of early embryos by damaging mitochondrial function and histone modification
作者:Chen, Fan;Luo, An-Feng;Pan, Kai-Xin;Gu, Hao;Zhou, Chang-Fan;Zeng, Wei;Liu, Song;Molenaar, Adrian;Ren, Hong-Yan;Bi, Yan-Zhen;Bi, Yan-Zhen;Huo, Li-Jun;Molenaar, Adrian
关键词:PNMC; Early embryonic development; Maternal-to-zygotic transition; Zygotic genome activation; Mitochondria; Histone modification
-
Overexpression of miR-192 Inhibits In Vitro Porcine Embryo Development by Inducing Oxidative Stress Damage and Impairing Mitochondrial Function
作者:He, Fan;Li, Mingguo;Qi, Mengfan;Fu, Binbin;Zhang, Huapeng;Li, Qingchun;Huang, Tao;Li, Mingguo;Chen, Fan;Bi, Yanzhen;Zhou, Rong;Huang, Tao
关键词:pig; miR-192; early embryo development
-
What does the dairy farming bring to the desertified soil? A case study
作者:Han, Zixi;Zeng, Jianfei;Dong, Yanyan;Wei, Sha;Han, Zixi;Zhao, Xu;Hou, Yong;Han, Zixi;Zhao, Xu;Mu, Yongsong;Han, Ziyu;Han, Ziyu
关键词:Dairy farming; Crop and livestock integration soil; improvement; Carbon footprint; Life cycle assessment
-
Integrated nutrient management in crop-livestock systems in China contributes to achieving safe planetary boundaries for nitrogen and phosphorus
作者:Zhang, Tao;Zhang, Tao;Hou, Yong;Fang, Qunchao;Oenema, Oene;Zhang, Tao;Zhu, Xueqin;Weikard, Hans-Peter;Tan, Meixiu;Oenema, Oene;Ma, Yifei
关键词:Crop production; Fertilizer use; Manure management; Nitrogen; Phosphorus; Mitigation measures
-
Nuclearporin subcomplex Nup98/Rae1 is vital for maternal-to-zygotic transition during early embryonic development
作者:Luo, Anfeng;Gu, Hao;Qi, Mengfan;Pan, Kaixin;Zhou, Changfan;Zeng, Wei;Liu, Song;Ren, Hongyan;Bi, Yanzhen;Chen, Fan;Bi, Yanzhen;Ali, Akhtar
关键词:Nup98; Rae1; Early embryonic development; Zygotic genome activation; Histone modification
-
A new strategy of molecular breeding for optimal heading date and grain yield in rice by modulating elite allelic combinations of Ghd7, Hd3a, RFT1 and Gn1a
作者:Su, Qingmei;Zhang, Yuhang;Zhu, Li;Qian, Qian;Su, Qingmei;Zhao, Mengyue;Zhu, Guanlin;Zhang, Fang;Chen, Fan;Wang, Rongsheng;Qian, Qian;Chen, Fan;Feng, Xiaomin;Wang, Qing;Qian, Qian;Chen, Fan;Wang, Rongsheng;Feng, Xiaomin;Lin, Shaoyang;Zhang, Yuhang;Zhu, Li;Qian, Qian
关键词:Adaptation; Elite gene combinations; Oryza sativa; Photoperiod response
-
Effects of Plant Growth Regulators on Magnesium Absorption and Fruit Quality in "Vitis vinifera cv. Shine-Muscat" Grape
作者:Wang, Qiangfeng;Yang, Yunyue;Wang, Haitao;Hou, Yong;Xia, Zhongmei
关键词:RNA sequencing; Organic acid targeted metabolomics; GC-MS