Enantioseparation Performance Tuning of Novel Cyclodextrin Chiral Separation Materials via Click Chemistry

文献类型： 外文期刊

第一作者： Wu Zhi-Hua

作者： Wu Zhi-Hua;Li Shen;Wang Yong;Zhao Jie;Wang Yong

作者机构：

关键词： High performance liquid chromatography;Cyclodextrin;Chiral stationary phase;Click chemistry

期刊名称：CHINESE JOURNAL OF ANALYTICAL CHEMISTRY （ 影响因子：1.134； 五年影响因子：0.909 ）

ISSN： 0253-3820

年卷期： 2016 年 44 卷 1 期

页码：

收录情况： SCI

摘要： This work fabricates four novel chiral stationary phases (CSPs) by tuning the functionality on cyclodextrin (CD) small mouth via click chemistry. Mono-6-deoxy-azido CD was anchored onto silica surface via ether linkage, followed by introducing tert. butyl, phenyl, ester and hydroxyl groups to the azido CD silica respectively. The as-prepared four novel CD CSPs were characterized by FTIR and elemental analysis. 16 enantiomer pairs including isoxazolines and dansyl amino acids could be baseline or partially separated on the current CD CSPs under reversed-phase separation mode. Ester functionalized CD CSP exhibited good chiral recognition towards isoxazolines and the resolution of 2-chlorphenyl-isoxazole (2ClPh-OPr) reached 1.62. The optimum pH for the separation of dansyl amino acids was 5.0. Among the prepared CSPs, Tert-butyl functionalized CD CSP had the best enantioseparation performance towards dansyl amino acids with most of the analytes baseline separated (R-s > 1.5).

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