The integrity of PRRSV nucleocapsid protein is necessary for up-regulation of optimal interleukin-10 through NF-kappa B and p38 MAPK pathways in porcine alveolar macrophages
文献类型: 外文期刊
第一作者: Liu, Yanyan
作者: Liu, Yanyan;Zhang, Yuyu;Zhu, Xiwang;Ren, Sufang;Guo, Lihui;Sun, Wenbo;Chen, Zhi;Cong, Xiaoyan;Chen, Lei;Du, Yijun;Li, Jun;Wu, Jiaqiang;Wang, Jinbao;Yu, Jiang;Liu, Yanyan;Zhang, Yuyu;Zhu, Xiwang;Ren, Sufang;Guo, Lihui;Sun, Wenbo;Chen, Zhi;Cong, Xiaoyan;Chen, Lei;Shi, Jianli;Du, Yijun;Li, Jun;Wu, Jiaqiang;Wang, Jinbao;Liu, Yanyan;Zhu, Xiwang;Wu, Jiaqiang;Wang, Jinbao;Liu, Xing
作者机构:
关键词: PRRSV;Nucleocapsid;Interleukin-10;Immunosuppression;Porcine alveolar macrophages
期刊名称:MICROBIAL PATHOGENESIS ( 影响因子:3.738; 五年影响因子:3.663 )
ISSN: 0882-4010
年卷期: 2017 年 109 卷
页码:
收录情况: SCI
摘要: Porcine reproductive and respiratory syndrome (PRRS), a highly contagious disease, has been constantly causing huge economic losses all over the world. PRRS virus (PRRSV) infection results in immunosuppression and IL-10 up-regulation. The relationship between them is still in dispute. Previous studies demonstrated the protein of PRRSV nucleocapsid (N) protein is able to up-regulate IL-10, yet the underlying molecular mechanisms remain unknown. In this study, the expression kinetics of IL-10 up regulation induced by PRRSV N protein were analyzed in immortalized porcine alveolar macrophages (PAM5). N protein induced IL-10 expression in a time- and dose-dependent manner. Inhibition experiments of signaling pathways suggested NF-kappa B and p38 MAPK pathways are both involved in N protein induced IL-10 up-regulation. Besides, the integrity of N protein is essential for significant IL-10 up regulation. This research is beneficial for further understanding of the interplay between PRRSV and host immune system.(C) 2017 Published by Elsevier Ltd.
分类号:
- 相关文献
作者其他论文 更多>>
-
Antibacterial mechanism of vitamin C against Staphylococcus aureus, reduction of toxicity of metabolites and its application in pasteurized milk
作者:Tian, Lei;Huang, Chunyang;Liu, Xing;Zhang, Yuxin;Zhang, Chunling;Wang, Xin;Zhou, Ting;Yu, Ying;Pan, Hu;Dai, Yanna;Pu, Jifeng;Fu, Chengyu;Zhang, Pengfei
关键词:Vitamin C; Staphylococcus aureus; Antibacterial mechanism; Pasteurized milk
-
Long-term effects of nitrogen fertilization and Bradyrhizobium inoculation on diazotrophic community structure and diversity in soybean cultivation
作者:Wei, Wanling;Ma, Mingchao;Jiang, Xin;Fan, Fenliang;Cao, Fengming;Chen, Huijun;Guan, Dawei;Li, Li;Li, Jun;Ma, Mingchao;Jiang, Xin;Cao, Fengming;Li, Li;Li, Jun;Meng, Fangang
关键词:Diazotrophs; Bradyrhizobium; nifH gene; Soil diversity
-
Single-cell transcriptome atlas of lamprey exploring Natterin- induced white adipose tissue browning
作者:Pang, Yue;Du, Zeyu;Zhang, Jin;Lu, Jiali;Li, Jun;Dong, Xinrui;Zhao, Zhisheng;Chuan, Shunqin;Sun, Mingjie;Li, Qingwei;Pang, Yue;Du, Zeyu;Zhang, Jin;Lu, Jiali;Li, Jun;Dong, Xinrui;Zhao, Zhisheng;Chuan, Shunqin;Sun, Mingjie;Li, Qingwei;Qin, Yating;Liu, Qun;Han, Kai;Yuan, Zengbao;Pan, Shanshan;Xu, Mengyang;Wang, Dantong;Li, Zhen;Chen, Yadong;Song, Yue;Zhan, Liping;Cui, Wei;Wang, Jun;Fan, Guangyi;Qin, Yating;Liu, Qun;Han, Kai;Fan, Guangyi;Qin, Yating;Liu, Qun;Han, Kai;Song, Yue;Qin, Yating;Fan, Guangyi;Yuan, Zengbao;Xu, Mengyang;Wang, Dantong;Gu, Ying;Yang, Huanming;Xu, Xun;Liu, Xin;Fan, Guangyi;Xu, Mengyang;Fan, Guangyi;Li, Shuo;Zhang, Zhe;Ni, Ming;Jia, Xiaodong;Xia, Zhangyong;Yue, Zhen;Fan, Guangyi;Gu, Ying;Yang, Huanming;Xu, Xun;Liu, Xin
关键词:
-
An idea for marine ranching planning based on ocean currents and its practice in Zhongjieshan Archipelago National Marine Ranching, China
作者:Tang, Shengming;Xu, Peng;Zhang, Shouyu;Gao, Junqi;Yin, Yuqi;Yin, Yuqi;Liang, Jun;Xu, Kaida;Jiang, Yazhou;Li, Jun;Feng, Jianlong
关键词:Maring ranching planning; Coastal currents; Zhongjieshan Archipelago; Zhoushan Archipelago; Drifters
-
Interactions, properties and lipid digestibility of attractive Pickering emulgels formed by sequential addition of oppositely charged nanopolysaccharides
作者:Guo, Shasha;Ji, Xingxiang;Guo, Shasha;Li, Jun;Huang, Luyao;Guo, Shasha;Wan, Zhangmin;Niu, Xun;Xu, Junhua;Liu, Ying;Bai, Long;Lu, Yi;Rojas, Orlando J.;Jiao, Wenjuan;Zheng, Jianan;Li, Bin;Bai, Long;Lu, Yi;Rojas, Orlando J.;Rojas, Orlando J.
关键词:
-
Design, synthesis, and antibacterial activity of novel amide derivatives containing a sulfone moiety
作者:Zou, Yue;Liu, Xing;Zhu, Zongnan;Zhang, Yong;Chen, Jixiang;Zhang, Chao;Zhao, Yuanzheng;Zhu, Xiang
关键词:Sulfone; Amide; Antibacterial activity; Structure-activity relationship
-
Dietary Methionine Restriction Alleviates Cognitive Impairment in Alzheimer's Disease Mice via Sex-Dependent Modulation on Gut Microbiota and Tryptophan Metabolism: A Multiomics Analysis
作者:Zhang, Yuyu;Li, Yiju;Wang, Da;Pang, Jingxi;Sang, Haojie;Xi, Yujia;Liu, Zhigang;Liu, Tianqi;Shi, Lin;Pan, Fei;Li, Yiju;Liu, Zhigang
关键词:Alzheimer's disease; methionine restriction; sexual dimorphism; indole-3-propionic acid; peroxisome proliferator-activated receptor alpha; multiomics